ReviewExpert review of vaccines2015
"Let there be light": the role of vitamin D in the immune response to vaccines.
Review in Expert review of vaccines, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 63 citations in OpenAlex.
- Trial
- The Effect of Vitamin D on the Humoral Immune Response of Calves to the Sheeppox Virus Vaccine.Archives of Razi Institute · 2025Article
- Understanding and improving vaccine efficacy in older adults.Nature aging · 2025Review
- Impact of vitamin D levels on mortality in older covid-19 vaccinated patients.BMC geriatrics · 2025Article
- Impact of vitamin D and zinc sufficiency on immune responses following COVID-19 vaccinations among healthcare workers.Clinical and experimental vaccine research · 2025Article
- Vitamin D as an Adjuvant Immune Enhancer to SARS-Cov-2 Vaccine.Current microbiology · 2025Article
- Impact of vitamin D on COVID-19 and other viral diseases.World journal of virology · 2024Article
- The active form of vitamin D (calcitriol) promotes CXCR5 expression during follicular helper T cell differentiation.International immunology · 2024Article
- Article
- Association between Vitamin D Deficiency and Serologic Response to Hepatitis B Virus Vaccination among Heavy Industry Workers.Vaccines · 2024Article
- Association of systemic vitamin D on the course of dengue virus infection in adults: a single-centre dengue cohort study at a large institution in Singapore.Singapore medical journal · 2024Article
- Vitamin D Levels as a Potential Modifier of Eosinophilic Esophagitis Severity in Adults.Digestive diseases and sciences · 2024Article
- Vaccinomics and adversomics: key elements for a personalized vaccinology.Clinical and experimental vaccine research · 2024Review
- VDR mRNA Expression And Serum Vitamin D Levels in Post-Covid Vaccinated Patients.F1000Research · 2024Article
- Exploring the Effects of Vitamin D and Vitamin A Levels on the Response to COVID-19 Vaccine.Vaccines · 2023Article
- Determination of the fate of Cholecalciferol injected by the basis of 25D3 plasma concentration.Scientific reports · 2023Article
- Towards a Future of Personalized Vaccinology: Study on Individual Variables Influencing the Antibody Response to the COVID-19 Vaccine.Vaccines · 2023Article
- DYNAMIC cohort study evaluating metabolic predictors of influenza vaccine immune response in older adults.NPJ vaccines · 2022Article
- Association of hepatitis B vaccine response to vitamin D supplementation and ultraviolet B (UVB) exposure during different time intervals in experimental animals.Immunologic research · 2022Article
- Age and vitamin D affect the magnitude of the antibody response to the first dose of the SARS-CoV-2 BNT162b2 vaccine.Current research in translational medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Vitamin D's non-skeletal actions, including immunomodulatory role, have been increasingly recognized. Of significance, many immune cells are able to synthesize a biologically active form of vitamin D from circulating 25-hydroxyvitamin D with subsequent intracrine actions, and the vitamin D receptor is broadly distributed. In this review, we discuss vitamin D's potent role in innate and adaptive immune responses and published studies evaluating the impact of serum vitamin D, vitamin D gene pathway polymorphisms or empiric vitamin D supplementation on vaccine immunogenicity. We highlight existing knowledge gaps and propose the steps needed to advance the science and answer the question of whether vitamin D may prove valuable as a vaccine adjuvant for certain vaccines against infectious diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.