Evidence map›Paper›PMID 26325328›Full record

ArticleExperimental eye research2015

Correlation of ER stress and retinal degeneration in tubby mice.

Xue Cai, Lijuan Chen, James F McGinnis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental eye research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Xue CaiDepartment of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States. Electronic address: xue-cai@ouhsc.edu.
Lijuan ChenDepartment of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States.
James F McGinnisDepartment of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States; Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States; Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States. Electronic address: james-mcginnis@ouhsc.edu.
Dean McGee Eye Institute · US

Funding

UNDERSTANDING THE ROLE OF RETINOL DEHYDROGENASES RDH11 AND RDH12 IN VISIONP20RR017703 · NCRR · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CERESA, BRIAN P. · 2002 to 2011
$23.6M
P30-CENTER CORE GRANT FOR VISION RESEARCHP30EY021725 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Michelle C Callegan, MICHAEL H ELLIOTT · 2011 to 2026
$10.5M
Prolonged Inhibition of Pathologic Neovascularization by Catalytic AntioxidantsR01EY022111 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI MCGINNIS, JAMES FRANCIS · 2012 to 2015
$2.2M
Prevention of Inherited Retinal Diseases by Therapeutic Rare Earth NanoparticlesR01EY018724 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI MCGINNIS, JAMES FRANCIS · 2009 to 2010
$738k
Pharmacokinetics of Therapeutic Nanoparticles in the CNSR21EY018306 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI MCGINNIS, JAMES FRANCIS · 2007 to 2009
$555k
NCRR NIH HHS P20 RR017703NEI NIH HHS P30 EY021725NEI NIH HHS R01 EY018724NEI NIH HHS R01EY018724NEI NIH HHS R01 EY022111NEI NIH HHS R01EY022111NEI NIH HHS R21 EY018306NEI NIH HHS R21EY018306
6 · The paper itself

Abstract

Mutation of the Tub gene results in the mislocalization of photoreceptor-specific proteins and eventually retinal degeneration. However, the exact mechanism underlying the retinal degeneration remains largely unknown. In this study, we discovered that the expression of endoplasmic reticulum (ER) stress markers, IRE1, ATF6, eIF2α, GRP78/BiP, and XBP-1, is up regulated during tubby retinal development. The dynamics of the expression of these genes are time-dependent and coincided with the time-course of photoreceptor death. Our data also demonstrated that ER stress triggers apoptosis via down-regulation of Bcl2, up-regulation of CHOP and the activation of NF-кB signaling.

Indexed as

Activating Transcription Factor 6Adaptor Proteins, Signal TransducingAnimalsApoptosisBiomarkersBlotting, WesternDNA-Binding ProteinsEndoplasmic Reticulum Chaperone BiPEndoplasmic Reticulum StressFluorescent Antibody Technique, IndirectHeat-Shock ProteinsMembrane ProteinsMiceMice, Inbred C57BLProtein Serine-Threonine KinasesReal-Time Polymerase Chain ReactionActivating Transcription Factor 6Adaptor Proteins, Signal TransducingAtf6 protein, mouseBiomarkersDNA-Binding ProteinsElf2 protein, mouseEndoplasmic Reticulum Chaperone BiPErn2 protein, mouseHeat-Shock ProteinsHspa5 protein, mouseMembrane ProteinsProtein Serine-Threonine KinasesTranscription FactorsTub protein, mouseApoptosisDownstream regulationER stressRetinal degenerationTubby mouse

Identifiers

PMID26325328
PMCPMC4624508
OpenAlexW1263674740

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.