ArticleInternational journal of pharmaceutics2015
Prediction of dexamethasone release from PLGA microspheres prepared with polymer blends using a design of experiment approach.
Article in International journal of pharmaceutics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Release mechanisms of PLGA-based drug delivery systems: A review.International journal of pharmaceutics: X · 2025Article
- Development of a 'green' wound healing hydrogel rich in apigenin-7-O-glucoside using an ultrasonication-assisted solvent extract of tomatoes.3 Biotech · 2025Article
- Development and Application of a Novel 'Green' Antibacterial Black Garlic (Food technology and biotechnology · 2025Article
- Acceleration of Final Residual Solvent Extraction From Poly(lactide-co-glycolide) Microparticles.Pharmaceutical research · 2024Article
- Optimizing Process Parameters for Controlled Drug Delivery: A Quality by Design (QbD) Approach in Naltrexone Microspheres.AAPS PharmSciTech · 2024Article
- Latest advances: Improving the anti-inflammatory and immunomodulatory properties of PEEK materials.Materials today. Bio · 2023Review
- Transscleral Delivery of Dexamethasone-Loaded Microparticles Using a Dissolving Microneedle Array.Pharmaceutics · 2023Article
- Preparation and characterization of morphine gelatine microspheres.Designed monomers and polymers · 2023Article
- Ultrahigh efficient emulsification with drag-reducing liquid gating interfacial behavior.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Dexamethasone-Loaded biodegradable magnetic microparticles for treatment of CFA-induced chronic pain in rats.Designed monomers and polymers · 2022Article
- Sustained delivery of 17β-estradiol by human amniotic extracellular matrix (HAECM) scaffold integrated with PLGA microspheres for endometrium regeneration.Drug delivery · 2020Article
- Development and Statistical Optimization of Solid Lipid Nanoparticle Formulations of Fluticasone Propionate.Turkish journal of pharmaceutical sciences · 2020Article
- Proton Oriented-"Smart Depot" for Responsive Release of CaPharmaceutical research · 2019Article
- PLGA microsphere/PVA hydrogel coatings suppress the foreign body reaction for 6 months.Journal of controlled release : official journal of the Controlled Release Society · 2018Article
- Optimization of self-microemulsifying drug delivery system for phospholipid complex of telmisartan using D-optimal mixture design.PloS one · 2018Article
- Control-released basic fibroblast growth factor-loaded poly-lactic-co-glycolic acid microspheres promote sciatic nerve regeneration in rats.Experimental and therapeutic medicine · 2017Article
- Preparation, Optimization and Toxicity Evaluation of (SPION-PLGA) ±PEG Nanoparticles Loaded with Gemcitabine as a Multifunctional Nanoparticle for Therapeutic and Diagnostic Applications.Iranian journal of pharmaceutical research : IJPR · 2017Article
- Seeing is believing, PLGA microsphere degradation revealed in PLGA microsphere/PVA hydrogel composites.Journal of controlled release : official journal of the Controlled Release Society · 2016Article
- In vitro and in vivo performance of dexamethasone loaded PLGA microspheres prepared using polymer blends.International journal of pharmaceutics · 2015Article
- Composites of Polymer Hydrogels and Nanoparticulate Systems for Biomedical and Pharmaceutical Applications.Nanomaterials (Basel, Switzerland) · 2015Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Hydrophobic drug release from poly (lactic-co-glycolic acid) (PLGA) microspheres typically exhibits a tri-phasic profile with a burst release phase followed by a lag phase and a secondary release phase. High burst release can be associated with adverse effects and the efficacy of the formulation cannot be ensured during a long lag phase. Accordingly, the development of a long-acting microsphere product requires optimization of all drug release phases. The purpose of the current study was to investigate whether a blend of low and high molecular weight polymers can be used to reduce the burst release and eliminate/minimize the lag phase. A single emulsion solvent evaporation method was used to prepare microspheres using blends of two PLGA polymers (PLGA5050 (25 kDa) and PLGA9010 (113 kDa)). A central composite design approach was applied to investigate the effect of formulation composition on dexamethasone release from these microspheres. Mathematical models obtained from this design of experiments study were utilized to generate a design space with maximized microsphere drug loading and reduced burst release. Specifically, a drug loading close to 15% can be achieved and a burst release less than 10% when a composition of 80% PLGA9010 and 90 mg of dexamethasone is used. In order to better describe the lag phase, a heat map was generated based on dexamethasone release from the PLGA microsphere/PVA hydrogel composite coatings. Using the heat map an optimized formulation with minimum lag phase was selected. The microspheres were also characterized for particle size/size distribution, thermal properties and morphology. The particle size was demonstrated to be related to the polymer concentration and the ratio of the two polymers but not to the dexamethasone concentration.
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