ArticleProceedings of the National Academy of Sciences of the United States of America2015
spenito is required for sex determination in Drosophila melanogaster.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 58 citations in OpenAlex.
- NAT10 governs development through the Xrp1-mediated stress response rather than its RNA acetylation activity.Science advances · 2026Article
- Role of the m6A methyltransferase Mettl16 in Drosophila development.PLoS genetics · 2026Article
- WTAP tetramer ensures mEMBO reports · 2026Article
- A mdg4 retrotransposon screen for X-linked female sterile alleles and its relationship with the transcription factor OVO.G3 (Bethesda, Md.) · 2026Article
- Sexually dimorphic ATF4 expression in the fat confers female stress tolerance in Drosophila melanogaster.Genetics · 2026Article
- Spen and Nito prevent dedifferentiation of intermediate progenitors by maintaining Notch target expression in stem cells at low levels.Cell reports · 2026Article
- AbioRxiv : the preprint server for biology · 2026Article
- Alternative splicing of squid is associated with sex-ratio allocation in the wasp Copidosomopsis nacoleiae.BMC genomics · 2025Article
- Review
- Dynamics and regulatory roles of RNA meLife · 2025Article
- Structures and mechanisms of the RNA mActa biochimica et biophysica Sinica · 2024Review
- Transcriptomic basis of sex loss in the pea aphid.BMC genomics · 2024Article
- Article
- NInsect biochemistry and molecular biology · 2023Article
- SPOC domain proteins in health and disease.Genes & development · 2023Review
- Spenito-dependent metabolic sexual dimorphism intrinsic to fat storage cells.bioRxiv : the preprint server for biology · 2023Article
- Biallelic loss-of-function variants in the splicing regulator NSRP1 cause a severe neurodevelopmental disorder with spastic cerebral palsy and epilepsy.Genetics in medicine : official journal of the American College of Medical Genetics · 2021Article
- Role of Hakai in mNature communications · 2021Article
- Spen modulates lipid droplet content in adult Drosophila glial cells and protects against paraquat toxicity.Scientific reports · 2020Article
- Occurrence and Functions of mPlant physiology · 2020Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Sex-lethal (Sxl) encodes the master regulator of the sex determination pathway in Drosophila and acts by controlling sex identity in both soma and germ line. In females Sxl maintains its own expression by controlling the alternative splicing of its own mRNA. Here, we identify a novel sex determination gene, spenito (nito) that encodes a SPEN family protein. Loss of nito activity results in stem cell tumors in the female germ line as well as female-to-male somatic transformations. We show that Nito is a ubiquitous nuclear protein that controls the alternative splicing of the Sxl mRNA by interacting with Sxl protein and pre-mRNA, suggesting that it is directly involved in Sxl auto-regulation. Given that SPEN family proteins are frequently mutated in cancers, our results suggest that these factors might be implicated in tumorigenesis through splicing regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.