Evidence map›Paper›PMID 26324884›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2015

Chronophin coordinates cell leading edge dynamics by controlling active cofilin levels.

Violaine Delorme-Walker, Ji-Yeon Seo, Antje Gohla, Bruce Fowler, Ben Bohl, Céline DerMardirossian

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. MARCKS and PI(4,5)PMolecular biology of the cell · 2024
    Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Cofilin: A Promising Protein Implicated in Cancer Metastasis and Apoptosis.Frontiers in cell and developmental biology · 2021
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Violaine Delorme-WalkerDepartment of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037; Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037;
Ji-Yeon SeoDepartment of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037; Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037;
Antje GohlaDepartment of Pharmacology, University of Würzburg, 97078 Wurzburg, Germany.
Bruce FowlerDepartment of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037; Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037;
Ben BohlDepartment of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037; Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037;
Céline DerMardirossianDepartment of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037; Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037; dmceline@scripps.edu.
Scripps Research Institute · USUniversity of Würzburg · DE

Funding

RHO GTPASES IN ADHESION/CHEMOATTRACTANT RECEPTOR CROSSTR01GM044428 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI DERMARDIROSSIAN, CELINE · 1991 to 2010
$4.4M
NIGMS NIH HHS GM44428NIGMS NIH HHS R01 GM044428
6 · The paper itself

Abstract

Cofilin, a critical player of actin dynamics, is spatially and temporally regulated to control the direction and force of membrane extension required for cell locomotion. In carcinoma cells, although the signaling pathways regulating cofilin activity to control cell direction have been established, the molecular machinery required to generate the force of the protrusion remains unclear. We show that the cofilin phosphatase chronophin (CIN) spatiotemporally regulates cofilin activity at the cell edge to generate persistent membrane extension. We show that CIN translocates to the leading edge in a PI3-kinase-, Rac1-, and cofilin-dependent manner after EGF stimulation to activate cofilin, promotes actin free barbed end formation, accelerates actin turnover, and enhances membrane protrusion. In addition, we establish that CIN is crucial for the balance of protrusion/retraction events during cell migration. Thus, CIN coordinates the leading edge dynamics by controlling active cofilin levels to promote MTLn3 cell protrusion.

Indexed as

Gene Expression RegulationActin Depolymerizing FactorsActinsAnimalsBreast NeoplasmsCell AdhesionCell Line, TumorCell MovementCofilin 1ErbB ReceptorsHumansMicrofilament ProteinsNeoplasm MetastasisPhosphatidylinositol 3-KinasesPhosphoprotein PhosphatasesRatsActin Depolymerizing FactorsActinsCFL1 protein, humanCfl1 protein, ratCofilin 1ErbB ReceptorsMicrofilament ProteinsPDXP protein, humanPhosphatidylinositol 3-KinasesPhosphoprotein Phosphatasesactin dynamicscancer cellscell protrusionchronophincofilin

Identifiers

PMID26324884
PMCPMC4577135
OpenAlexW1930815221

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.