ReviewEuropean respiratory review : an official journal of the European Respiratory Society2015
Should lung biopsies be performed in patients with severe asthma?
Review in European respiratory review : an official journal of the European Respiratory Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Diagnosis and Management of Small Airways Disease.CHEST pulmonary · 2026Review
- Airway epithelial heterogeneity and mucus plugging in asthmatic bronchioles.American journal of respiratory and critical care medicine · 2026Article
- Advanced models for respiratory disease and drug studies.Medicinal research reviews · 2023Review
- Small airways in asthma: Pathophysiology, identification and management.Chinese medical journal pulmonary and critical care medicine · 2023Review
- Pulmonary inflammation promoted by type-2 dendritic cells is a feature of human and murine schistosomiasis.Nature communications · 2023Article
- Severe Adult Asthmas: Integrating Clinical Features, Biology, and Therapeutics to Improve Outcomes.American journal of respiratory and critical care medicine · 2021Review
- The potential of omics approaches to elucidate mechanisms of biodiesel-induced pulmonary toxicity.Particle and fibre toxicology · 2019Review
- Does transbronchial lung cryobiopsy give useful information in asthmatic patients?Multidisciplinary respiratory medicine · 2019Article
- Aberrant epithelial remodeling with impairment of cilia architecture in non-cystic fibrosis bronchiectasis.Journal of thoracic disease · 2018Article
- Article
- Histologic Findings of Severe/Therapy-Resistant Asthma From Video-assisted Thoracoscopic Surgery Biopsies.The American journal of surgical pathology · 2017Article
- High-resolution CT pulmonary findings in children with severe asthma.Jornal de pediatriaArticle
- Management of Severe Asthma before Referral to the Severe Asthma Specialist.The journal of allergy and clinical immunology. In practiceReview
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Asthma, and severe asthma, in particular, is increasingly recognised as a heterogeneous disease. Identifying these different phenotypes of asthma and assigning patients to phenotype-specific treatments is one of the current conundrums in respiratory medicine. Any diagnostic procedure in severe asthma (or any disease) should have two aims: 1) better understanding or identifying the diagnosis, and 2) providing information on the heterogeneity of asthma phenotypes to guide therapy with the objective of improving outcomes. Lung biopsies can target the large and small airways as well as the lung parenchyma. All compartments are affected in severe asthma; however, knowledge on the distal lung is limited. At this point, it remains uncertain whether lung specimens routinely add diagnostic information that is unable to be obtained otherwise. Indeed, whether a lung biopsy is indicated in the workup of a patient with severe asthma remains an individual decision. It is hoped this review will support rational decision-making and provide a detailed synopsis of the varied histopathological features seen in biopsies of patients with a diagnosis of severe asthma. Due to limited data on this topic this review is primarily based on opinion with recommendations arising primarily from the personal experience of the authors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.