ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2016
Frontotemporal Dementia and Psychiatric Illness: Emerging Clinical and Biological Links in Gene Carriers.
Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- The Differential Effects of Genetic Mutations in ALS and FTD Genes on Behavioural and Cognitive Changes: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2025Pooled it
- Advances in the Diagnosis and Management of Psychotic Symptoms in Neurodegenerative Diseases: A Narrative Review.Journal of geriatric psychiatry and neurology · 2023Review
- No Association of Multiple Sclerosis withInternational journal of molecular sciences · 2023Article
- Proposed research criteria for prodromal behavioural variant frontotemporal dementia.Brain : a journal of neurology · 2022Article
- Molecular imaging biomarkers in familial frontotemporal lobar degeneration: Progress and prospects.Frontiers in neurology · 2022Review
- C9orf72-Related Neurodegenerative Diseases: From Clinical Diagnosis to Therapeutic Strategies.Frontiers in aging neuroscience · 2022Review
- Schizophrenia syndrome due to C9ORF72 mutation case report: a cautionary tale and role of hybrid brain imaging!BMC psychiatry · 2021Article
- Unravelling the clinical spectrum and the role of repeat length inJournal of neurology, neurosurgery, and psychiatry · 2021Review
- Clinical and Neuroimaging Aspects of Familial Frontotemporal Lobar Degeneration Associated with MAPT and GRN Mutations.Advances in experimental medicine and biology · 2021Review
- What Do We Mean by Behavioral Disinhibition in Frontotemporal Dementia?Frontiers in neurology · 2021Review
- Frontotemporal Dementia and Late-Onset Bipolar Disorder: The Many Directions of a Busy Road.Frontiers in psychiatry · 2021Review
- The Neuropsychiatric Features of Behavioral Variant Frontotemporal Dementia.Advances in experimental medicine and biology · 2021Article
- Recommendations to distinguish behavioural variant frontotemporal dementia from psychiatric disorders.Brain : a journal of neurology · 2020Review
- Links Between the C9orf72 Repeat Expansion and Psychiatric Symptoms.Current neurology and neuroscience reports · 2019Review
- Article
- Psychiatric symptoms in preclinical behavioural-variant frontotemporal dementia inJournal of neurology, neurosurgery, and psychiatry · 2018Article
- The Confluence of Psychiatric Symptoms and Neurodegenerative Disease: Impact on Genetic Counseling.Journal of genetic counseling · 2017Article
- Bibliography: Clinical Neuropsychiatry.Focus (American Psychiatric Publishing) · 2016Article
- Molecular Pathways Bridging Frontotemporal Lobar Degeneration and Psychiatric Disorders.Frontiers in aging neuroscience · 2016Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo describe psychiatric presentations in individuals with genetic mutations causing frontotemporal dementia (FTD).
designCase descriptions from five carriers of FTD-related gene mutations with symptoms associated with non-neurodegenerative psychiatric disease.
settingA comprehensive research program investigating genetic and non-genetic FTD at the University of California, San Francisco Memory and Aging Center.
participantsThree proband and two non-proband gene carriers. MEASUREMENTS: Medical history and neurological examination, neuropsychological testing, magnetic resonance and/or positron emission tomography imaging, and a genetic analysis to screen for dementia-related mutations. Genetic status was unknown at the time of initial evaluation.
resultsThe chosen cases are illustrative of the variety of presentations of psychiatric symptoms in FTD gene carriers. In some cases, a non-neurodegenerative psychiatric illness was diagnosed based on specific symptoms, but the diagnosis may have been inappropriate based on the overall syndrome. In other cases, symptoms closely resembling those seen in non-neurodegenerative psychiatric illness did occur, in some cases immediately preceding the development of dementia, and in other cases developing a decade prior to dementia symptoms.
conclusionsPsychiatric symptoms in FTD gene carriers can be very similar to those seen in non-neurodegenerative psychiatric illness. Psychiatric symptoms with atypical features (e.g., late-life onset, insidiously worsening course) should prompt careful assessment for neurodegenerative disease. Guidelines for such an assessment should be established.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.