ReviewArthritis research & therapy2015
Wolff's law in action: a mechanism for early knee osteoarthritis.
Review in Arthritis research & therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Global prevalence estimates of diffuse idiopathic skeletal hyperostosis: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Pooled it
- The mechano-immune-vesicle regulatory circuit: a systems framework for bone homeostasis and regeneration.Bioactive materials · 2026Review
- Regional Differences in Knee Osteoporosis Based on Coronal Alignment Phenotype in Patients Undergoing Preoperative CT Imaging.Diagnostics (Basel, Switzerland) · 2026Article
- Coronal knee alignment is directly related to knee medial-to-lateral bone density ratio.Journal of experimental orthopaedics · 2026Article
- A Novel Concept of Tissue Micro-Instability as the Underlying Mechanism of Osteophytosis in Human Knee Osteoarthritis.Biomedicines · 2026Article
- The Aging Process of Facial Muscles.Journal of cosmetic dermatology · 2025Article
- CT-derived proximal tibial bone density imbalance is associated with knee osteoarthritis.Journal of orthopaedic surgery and research · 2025Article
- Amelioration of Post-traumatic Osteoarthritis by Iontophoretic Liposomal Strontium Ranelate Collaborated with Low-Intensity Pulsed Ultrasound in Rats.International journal of molecular sciences · 2025Article
- Development and validation of a nomogram for predicting low bone mineral density in male patients with ankylosing spondylitis.Frontiers in medicine · 2025Article
- The Etiology of Neuromuscular Hip Dysplasia and Implications for Management: A Narrative Review.Children (Basel, Switzerland) · 2024Review
- Significance of Selected Posturographic Methods in Diagnosis of Balance Disorders in Patients with Early-Stage Gonarthrosis.Journal of clinical medicine · 2024Article
- Load carriage changes tibiofemoral arthrokinematics during ambulatory tasks in recruit-aged women.Scientific reports · 2024Article
- Biomechanics of the Human Osteochondral Unit: A Systematic Review.Materials (Basel, Switzerland) · 2024Review
- Pathological progression of osteoarthritis: a perspective on subchondral bone.Frontiers of medicine · 2024Review
- Appearance and evolution of radiolucent lines below the tibial implant in primary total knee arthroplasty.Archives of orthopaedic and trauma surgery · 2024Article
- Biomechanical analysis of different techniques for residual bone defect from tibial plateau bone cyst in total knee arthroplasty.Frontiers in bioengineering and biotechnology · 2024Article
- Surface-based anthropomorphic bone structures for use in high-resolution simulated medical imaging.Physics in medicine and biology · 2023Article
- Vitamin D status associates with skeletal muscle loss after anterior cruciate ligament reconstruction.JCI insight · 2023Article
- Efficacy and safety of platelet-rich plasma combined with Tai Chi for knee osteoarthritis: study protocol for a placebo-controlled randomized trial.Journal of orthopaedic surgery and research · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is growing interest in the role of bone in knee osteoarthritis. Bone is a dynamic organ, tightly regulated by a multitude of homeostatic controls, including genetic and environmental factors. One such key environmental regulator of periarticular bone is mechanical stimulation, which, according to Wolff's law, is a key determinant of bone properties. Wolff's law theorizes that repetitive loading of bone will cause adaptive responses enabling the bone to better cope with these loads. Despite being an adaptive response of bone, the remodeling process may inadvertently trigger maladaptive responses in other articular structures. Accumulating evidence at the knee suggests that expanding articular bone surface area is driven by mechanical stimulation and is a strong predictor of articular cartilage loss. Similarly, fractal analysis of bone architecture provides further clues that bone adaptation may have untoward consequences for joint health. This review hypothesizes that adaptations of periarticular bone in response to mechanical stimulation cause maladaptive responses in other articular structures that mediate the development of knee osteoarthritis. A potential disease paradigm to account for such a hypothesis is also proposed, and novel therapeutic targets that may have a bone-modifying effect, and therefore potentially a disease-modifying effect, are also explored.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.