ReviewNature reviews. Nephrology2015
Strategies to overcome the ABO barrier in kidney transplantation.
Review in Nature reviews. Nephrology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- Association between ABO and Duffy blood types and circulating chemokines and cytokines.Genes and immunity · 2021Trial
- Repeat ABO-B-incompatible living-donor kidney transplantation.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026Article
- ABO-incompatible kidney transplantation with high isoagglutinin titres: practice pattern and problem solving: a German multi-centre survey.Frontiers in immunology · 2026Article
- Impact of IgG monitoring and machine learning based prediction on outcomes of ABO incompatible kidney transplantation in blood type O recipients.Scientific reports · 2025Article
- Article
- Similarities and Differences Between Allogeneic Hematopoietic Cell and Organ Transplantation and What We Can Learn From Each Other to Guide Global Health Strategy.Clinical transplantation · 2025Review
- ABO Antibody Titer Testing Harmonization in Korea: A 5-Year Analysis of External Quality Control Data.Annals of laboratory medicine · 2025Article
- Enzymatic conversion of blood group B kidney prevents hyperacute antibody-mediated injuries in ABO-incompatible transplantation.Nature communications · 2025Article
- Enzymatic conversion of human blood group A kidneys to universal blood group O.Nature communications · 2024Article
- C1q Binding Ability for Prior Risk Assessment of Acute Antibody-Mediated Rejection in ABO-Incompatible Kidney Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2024Article
- Outcomes of ABO-incompatible liver transplantation in end-stage liver disease patients co-infected with hepatitis B and human immunodeficiency virus.World journal of gastroenterology · 2023Article
- Enzymatic blood group conversion of human kidneys during ex vivo normothermic machine perfusion.The British journal of surgery · 2023Article
- Laboratory support of ABO antibody monitoring for ABO-incompatible solid organ transplantation.Korean journal of transplantation · 2022Review
- Evaluation of Erythrocytes Magnetized Technology for Measurement of ABO Isoagglutinin Titers.Journal of laboratory physicians · 2022Article
- ABO-Incompatibility: Time to Challenge the Paradigm of Equivalence in Live-Donor Kidney Transplantation?Transplant international : official journal of the European Society for Organ Transplantation · 2022Article
- Progression of histological lesions after ABO incompatible kidney transplantation.Frontiers in immunology · 2022Article
- Current Perspectives in ABO-Incompatible Kidney Transplant.Journal of inflammation research · 2022Review
- Protection of transplants against antibody-mediated injuries: from xenotransplantation to allogeneic transplantation, mechanisms and therapeutic insights.Frontiers in immunology · 2022Review
- ABO-incompatible kidney transplantation in perspective of deceased donor transplantation and induction strategies: a propensity-matched analysis.Transplant international : official journal of the European Society for Organ Transplantation · 2021Article
- Acute Rejection and Infectious Complications in ABO- and HLA-Incompatible Kidney Transplantations.Annals of transplantation · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kidney transplantation across the ABO blood group barrier was long considered a contraindication for transplantation, but in an effort to increase donor pools, specific regimens for ABO-incompatible (ABOi) transplantation have been developed. These regimens are now widely used as an integral part of the available treatment options. Various desensitization protocols, commonly based on transient depletion of preformed anti-A and/or anti-B antibodies and modulation of B-cell immunity, enable excellent transplant outcomes, even in the long-term. Nevertheless, the molecular mechanisms behind transplant acceptance facilitated by a short course of anti-humoral treatment are still incompletely understood. With the evolution of efficient clinical programmes, tailoring of recipient preconditioning based on individual donor-recipient blood type combinations and the levels of pretransplant anti-A/B antibodies has become possible. In the context of low antibody titres and/or donor A2 phenotype, immunomodulation and/or apheresis might be dispensable. A concern still exists, however, that ABOi kidney transplantation is associated with an increased risk of surgical and infectious complications, partly owing to the effects of extracorporeal treatment and intensified immunosuppression. Nevertheless, a continuous improvement in desensitization strategies, with the aim of minimizing the immunosuppressive burden, might pave the way to clinical outcomes that are comparable to those achieved in ABO-compatible transplantation.
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