ArticleWorld journal of surgery2016
FDG PET/CT Scan and Functional Adrenal Tumors: A Pilot Study for Lateralization.
Article in World journal of surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- [Novel imaging techniques for the differential diagnosis of adrenal tumors, pheochromocytomas and paragangliomas].Chirurgie (Heidelberg, Germany) · 2026Review
- Addressing the Clinical Conundrum of Localization in ACTH-independent Cushing Syndrome With Bilateral Adrenal Nodules.JCEM case reports · 2025Article
- The value of targeted CXCR4Frontiers in endocrinology · 2025Article
- Atypical Imaging Findings in a Cortisol-producing Adrenal Adenoma Predominantly Composed of Lipid-poor Compact Cells.JCEM case reports · 2024Article
- Article
- 18F-FDG-PET/CT Evaluation of Indeterminate Adrenal Masses in Noncancer Patients.The Journal of clinical endocrinology and metabolism · 2021Article
- Adrenal Vein Cortisol to Metanephrine Ratio for Localizing ACTH-Independent Cortisol-Producing Adenoma: A Case Report.Journal of the Endocrine Society · 2021Article
- Hypoxia-induced modulation of glucose transporter expression impactsEuropean journal of nuclear medicine and molecular imaging · 2020Article
- Diagnostic efficacy of 18F-FDG PET/CT in patients with adrenal incidentaloma.Endocrine connections · 2019Article
- Outcomes of Adrenal Venous Sampling in Patients with Bilateral Adrenal Masses and ACTH-Independent Cushing's Syndrome.World journal of surgery · 2019Article
- The computed tomography adrenal wash-out analysis properly classifies cortisol secreting adrenocortical adenomas.Endocrine · 2018Article
- Benign hormone-secreting adenoma within a larger adrenocortical mass showing intensely increased activity onEndocrine · 2016Article
- Increased F-FDG Uptake in Bilateral Gynecomastia Secondary to Feminizing Adrenal Tumor: A Rare Case Report and Review of Literature.Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, IndiaArticle
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundPatients with Cushing's Syndrome (CS) and Conn's Syndrome with bilateral adrenal masses pose a dilemma. Uptake of 18F-FDG by hyperfunctioning adrenal glands has not been previously reported and may help lateralize. The aim was to determine if 18F-FDG PET/CT scan could identify hyperfunctioning adrenal masses and determine a biological basis for uptake.
methodsPatients with nonfunctional adenomas (n = 9), CS (n = 11), and Conn's syndrome (n = 4) underwent an 18F-FDG PET/CT scan with a volume of interest circumscribing each mass to obtain a maximal standardized uptake value (SUVmax). Thirty-two adrenal masses were analyzed. Genome-wide expression data from an independent cohort were analyzed in nonfunctioning adenomas (n = 20), Conn's syndrome (n = 29), and CS (n = 24) focusing on GLUT genes. For genes differentially expressed, immunohistochemistry was performed on tissue samples.
resultsCortisol-secreting masses (n = 16) had a higher average SUVmax of 5.9 compared to nonfunctioning masses (n = 11, average SUVmax 4.2) and aldosterone-hypersecreting masses (n = 5, average SUVmax 3.2) (p = 0.007). SUVmax cut-off of 5.33 had 50.0% sensitivity and 81.8% specificity in localizing a cortisol-secreting mass. GLUT3 expression was 2.19-fold higher in patients with CS compared to patients with nonfunctioning adenomas (p = 0.003) and 2.16-fold higher in patients with CS compared to Conn's syndrome (p = 0.006). GLUT3 immunohistochemistry showed 2.2-fold higher staining in CS tumor samples compared to nonfunctioning adenomas.
conclusionsDifferential 18F-FDG PET/CT uptake was observed in patients with nonfunctioning, aldosterone-hypersecreting, and cortisol-secreting masses. GLUT3 overexpression in cortisol-secreting tumor likely accounts for the differential uptake. Future larger cohort studies will need to be conducted to determine if 18F-FDG PET/CT uptake can lateralize cortisol-secreting adrenal masses in patients with bilateral adrenal masses.
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