ArticleAge (Dordrecht, Netherlands)2015
Effects of aging on human leukocytes (part II): immunophenotyping of adaptive immune B and T cell subsets.
Article in Age (Dordrecht, Netherlands), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Comprehensive flow cytometric reference intervals of leukocyte subsets from six study centers across Europe.Clinical and experimental immunology · 2020Trial
- Inosine pranobex is safe and effective for the treatment of subjects with confirmed acute respiratory viral infections: analysis and subgroup analysis from a Phase 4, randomised, placebo-controlled, double-blind study.BMC infectious diseases · 2016Trial
- Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis.Frontiers in immunology · 2023Review
- Epidemiological features of tuberculosis infection in a rural prefecture of Japan from 2007 to 2018.Scientific reports · 2022Article
- Immunopathogenesis of patients with COVID-19: from the perspective of immune system 'evolution' and 'revolution'.Expert reviews in molecular medicine · 2022Review
- Analysis of T and NK cell subsets in the Sicilian population from young to supercentenarian: The role of age and gender.Clinical and experimental immunology · 2021Article
- Reduced RING finger protein 10 expression in macrophages is associated with aging-related inflammation.FEBS open bio · 2021Article
- The conundrum of human immune system "senescence".Mechanisms of ageing and development · 2020Review
- Correlation between immunity from BCG and the morbidity and mortality of COVID-19.Tropical diseases, travel medicine and vaccines · 2020Article
- Cryptococcal Meningitis in A Patient With Giant Cell Arteritis.Archives of rheumatology · 2017Article
- Age at onset is associated with the seasonal pattern of onset and exacerbation in inflammatory bowel disease.Journal of gastroenterology · 2017Observational
- Does the human immune system ever really become "senescent"?F1000Research · 2017Review
- Does tuberculosis threaten our ageing populations?BMC infectious diseases · 2016Review
- Changes in blood lymphocyte numbers with age in vivo and their association with the levels of cytokines/cytokine receptors.Immunity & ageing : I & A · 2016Article
- Characterization of γδ T-cells via flow cytometry.Age (Dordrecht, Netherlands) · 2015Article
- Effects of aging on human leukocytes (part I): immunophenotyping of innate immune cells.Age (Dordrecht, Netherlands) · 2015Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunosenescence results from a continuous deterioration of immune responses resulting in a decreased response to vaccines. A well-described age-related alteration of the immune system is the decrease of de novo generation of T and B cells. In addition, the accumulation of memory cells and loss of diversity in antigen specificities resulting from a lifetime of exposure to pathogens has also been described. However, the effect of aging on subsets of γδTCR(+) T cells and Tregs has been poorly described, and the efficacy of the recall response to common persistent infections in the elderly remains obscure. Here, we investigated alterations in the subpopulations of the B and T cells among 24 healthy young (aged 19-30) and 26 healthy elderly (aged 53-67) individuals. The analysis was performed by flow cytometry using freshly collected peripheral blood. γδTCR(+) T cells were overall decreased, while CD4(+)CD8(-) cells among γδTCR(+) T cells were increased in the elderly. Helios(+)Foxp3(+) and Helios(-)Foxp3(+) Treg cells were unaffected with age. Recent thymic emigrants, based on CD31 expression, were decreased among the Helios(+)Foxp3(+), but not the Helios(-)Foxp3(+) cell populations. We observed a decrease in Adenovirus-specific CD4(+) and CD8(+) T cells and an increase in CMV-specific CD4(+) T cells in the elderly. Similarly, INFγ(+)TNFα(+) double-positive cells were decreased among activated T cells after Adenovirus stimulation but increased after CMV stimulation. The data presented here indicate that γδTCR(+) T cells might stabilize B cells, and functional senescence might dominate at higher ages than those studied here.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.