ArticleMolecular psychiatry2016
High loading of polygenic risk in cases with chronic schizophrenia.
Article in Molecular psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 4 of them syntheses that pooled it.
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Who cites it
42 citing papers in PubMed, 4 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population.Molecular psychiatry · 2024Pooled it
- Psychotic relapse prediction via biomarker monitoring: a systematic review.Frontiers in psychiatry · 2024Pooled it
- Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.Nature genetics · 2018Pooled it
- Meta-Analyses of Genome-Wide Association Data Hold New Promise for Addiction Genetics.Journal of studies on alcohol and drugs · 2016Pooled it
- Genetics to Improve Outcomes in Schizophrenia (GENios): A within-case molecular genetic study protocol.PloS one · 2026Article
- Polygenic and Polyenvironment Interplay in Schizophrenia-Spectrum Disorder and Affective Psychosis; the EUGEI First Episode Study.Schizophrenia bulletin · 2025Article
- Polygenic Scores for Schizophrenia and Educational Attainment Predict Global Functioning Across Psychiatric Hospitalization Among People with Schizophrenia.medRxiv : the preprint server for health sciences · 2025Article
- Polygenic risk for schizophrenia and subjective well-being in a general population sample.Psychological medicine · 2025Article
- Sleep and schizophrenia polygenic scores in non-affective and affective psychotic disorders.Psychological medicine · 2025Article
- Assessing the validity of a self-reported clinical diagnosis of schizophrenia.Schizophrenia (Heidelberg, Germany) · 2024Article
- Association between psychiatric admissions in patients with schizophrenia and IL-6 plasma levels polygenic score.European archives of psychiatry and clinical neuroscience · 2024Article
- Assessing the validity of a self-reported clinical diagnosis of schizophrenia.medRxiv : the preprint server for health sciences · 2023Article
- Genomic findings in schizophrenia and their implications.Molecular psychiatry · 2023Review
- Use of multiple polygenic risk scores for distinguishing schizophrenia-spectrum disorder and affective psychosis categories in a first-episode sample; the EU-GEI study.Psychological medicine · 2023Article
- Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia, Bipolar Disorder, and Depression Among Adults in the US Veterans Affairs Health Care System.JAMA psychiatry · 2022Article
- Potential diagnostic biomarkers for schizophrenia.Medical review (2021) · 2022Review
- Role of polygenic and environmental factors in the co-occurrence of depression and psychosis symptoms: a network analysis.Translational psychiatry · 2022Article
- Genetic risk for psychiatric illness is associated with the number of hospitalizations of bipolar disorder patients.Journal of affective disorders · 2022Article
- Polygenic risk scores: An overview from bench to bedside for personalised medicine.Frontiers in genetics · 2022Review
- Pharmacogenetics of Antipsychotic Treatment in Schizophrenia.Methods in molecular biology (Clifton, N.J.) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 9 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genomic risk profile scores (GRPSs) have been shown to predict case-control status of schizophrenia (SCZ), albeit with varying sensitivity and specificity. The extent to which this variability in prediction accuracy is related to differences in sampling strategies is unknown. Danish population-based registers and Neonatal Biobanks were used to identify two independent incident data sets (denoted target and replication) comprising together 1861 cases with SCZ and 1706 controls. A third data set was a German prevalent sample with diagnoses assigned to 1773 SCZ cases and 2161 controls based on clinical interviews. GRPSs were calculated based on the genome-wide association results from the largest SCZ meta-analysis yet conducted. As measures of genetic risk prediction, Nagelkerke pseudo-R(2) and variance explained on the liability scale were calculated. GRPS for SCZ showed positive correlations with the number of psychiatric admissions across all P-value thresholds in both the incident and prevalent samples. In permutation-based test, Nagelkerke pseudo-R(2) values derived from samples enriched for frequently admitted cases were found to be significantly higher than for the full data sets (Ptarget=0.017, Preplication=0.04). Oversampling of frequently admitted cases further resulted in a higher proportion of variance explained on the liability scale (improvementtarget= 50%; improvementreplication= 162%). GRPSs are significantly correlated with chronicity of SCZ. Oversampling of cases with a high number of admissions significantly increased the amount of variance in liability explained by GRPS. This suggests that at least part of the effect of common single-nucleotide polymorphisms is on the deteriorative course of illness.
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