ArticleScientific reports2015
One-Step Synthesis of Chiral Oxindole-type Analogues with Potent Anti-inflammatory and Analgesic Activities.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Synthesis of Tetracyclic Spirooxindolepyrrolidine-Engrafted Hydantoin Scaffolds: Crystallographic Analysis, Molecular Docking Studies and Evaluation of Their Antimicrobial, Anti-Inflammatory and Analgesic Activities.Molecules (Basel, Switzerland) · 2023Article
- Investigating anti-inflammatory and apoptotic actions of fucoidan concentrating on computational and therapeutic applications.3 Biotech · 2023Article
- Anti-Inflammatory Effects ofJournal of inflammation research · 2022Article
- Anti-inflammatory activity of 3-cinnamoyltribuloside and its metabolomic analysis in LPS-activated RAW 264.7 cells.BMC complementary medicine and therapies · 2020Article
- Spiroindolone analogues bearing benzofuran moiety as a selective cyclooxygenase COX-1 with TNF-α and IL-6 inhibitors.Saudi journal of biological sciences · 2020Article
- Spiroindolone Analogues as Potential Hypoglycemic with Dual Inhibitory Activity on α-Amylase and α-Glucosidase.Molecules (Basel, Switzerland) · 2019Article
- Article
- Discovery of hybrids of indolin-2-one and nitroimidazole as potent inhibitors against drug-resistant bacteria.The Journal of antibiotics · 2018Article
- Synergy of Physico-chemical and Biological Experiments for Developing a Cyclooxygenase-2 Inhibitor.Scientific reports · 2018Article
- Diastereoselective synthesis of novel spiro indanone fused pyrano[3,2-RSC advances · 2018Article
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Authors and funding
11 authors.
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Abstract
Here we report a facile approach to synthesize highly optically active oxindole-type analogues with both high yield and enantioselectivity. This single-step synthesis strategy represents a substantial improvement upon existing methods that are often involved with multi-step routes and have suboptimal atomic economy. One such compound, namely Q4c, showed remarkable in vivo anti-inflammatory activity with efficiency approaching to that of a steroidal compound dexamethasone. Moreover, Q4c alleviated pain in mouse models with comparable activity to morphine. Further investigation suggested that nitric oxide signaling pathway is involved in the anti-inflammatory and analgesic activities of Q4c. Notably, this is the first time that chiral oxindole-type analogues have been identified to be both anti-inflammatory and analgesic, and our study also paved the way for future development of oxindoles as drug candidates in this field.
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