Evidence map›Paper›PMID 26323938›Full record

Trial reportThe New England journal of medicine2015

Adaptive Servo-Ventilation for Central Sleep Apnea in Systolic Heart Failure.

Martin R Cowie, Holger Woehrle, Karl Wegscheider, Christiane Angermann, Marie-Pia d'Ortho, Erland Erdmann, Patrick Levy, Anita K Simonds, Virend K Somers, Faiez Zannad and 1 more

2 registry-linked trialsOpen access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The New England journal of medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 394 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
394citing papers in PubMed, 9 pooled it
85.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00733343 nacompletednot on this map

Treatment of Sleep-Disordered Breathing With Predominant Central Sleep Apnea by Adaptive Servo Ventilation in Patients With Heart Failure

TypeinterventionalSponsorResMedRan2008 to 2015Enrolled1,325ConditionsHeart Failure, Sleep Disordered BreathingArmsEurope: AutoSet CS (USA: VPAP Adapt SV)
NCT05913739 naterminatednot on this mapstarted 2022, after this paper: background citation

Impact of Oxygen Therapy on Readmissions of Patients With Chronic Heart Failure With Reduced Ejection Fraction

TypeinterventionalSponsorInstitut d'Investigació Biomèdica de Girona Dr. Josep TruetaRan2022 to 2024Enrolled1ConditionsChronic Heart Failure, Oxygen DeficiencyArmsOxygen Therapy
3 · Its place in the literature

Who cites it

394 citing papers in PubMed, 9 syntheses or guidelines pooled it, 1,074 citations in OpenAlex.

  1. Pooled it
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  3. Guideline
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  5. Pharmacological treatment for central sleep apnoea in adults.The Cochrane database of systematic reviews · 2023
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  8. The role of acetazolamide in sleep apnea at sea level: a systematic review and meta-analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021
    Pooled it
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  10. Automatic activation of neurostimulation for central sleep apnea results in high nightly usage.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026
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  18. Automatic positive airway pressure for obstructive sleep apnea in heart failure with reduced ejection fraction.Clinical research in cardiology : official journal of the German Cardiac Society · 2021
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  20. Review

334 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 4 countries.

Martin R CowieFrom Imperial College London (M.R.C) and Royal Brompton Hospital (A.K.S.) - both in London; ResMed Science Center, ResMed Germany, Martinsried (H.W.), Sleep and Ventilation Center Blaubeuren, Respiratory Center Ulm, Ulm (H.W.), the Department of Medical Biometry and Epidemiology, University Medical Center Eppendorf, Hamburg (K.W.), the Department of Medicine I and Comprehensive Heart Failure Center, University Hospital and University of Würzburg, Würzburg (C.A.), Heart Center, University of Cologne, Cologne (E.E.), and the Department of Pneumology, Ruhrlandklinik, West German Lung Center, University Hospital Essen, University Duisburg-Essen, Essen (H.T.) - all in Germany; University Paris Diderot, Sorbonne Paris Cité, Hôpital Bichat, Explorations Fonctionnelles, Département Hospitalo-Universitaire Fight Inflammation and Remodeling, Assistance Publique-Hôpitaux de Paris, Paris (M-P.O.), Centre Hospitalier Universitaire (CHU) de Grenoble, Grenoble, (P.L.), and INSERM, Université de Lorraine, CHU de Nancy, Nancy (F.Z.) - all in France; and the Mayo Clinic and Mayo Foundation, Rochester, MN (V.K.S.).
Holger Woehrle
Karl Wegscheider
Christiane Angermann
Marie-Pia d'Ortho
Erland Erdmann
Patrick Levy
Anita K Simonds
Virend K Somers
Faiez Zannad
Helmut Teschler
Hôpital Bichat-Claude-Bernard · FRMayo Clinic · USResMed (Germany) · DERoyal Brompton Hospital · GBRuhrlandklinik · DEUniversität Hamburg · DEUniversité de Lorraine · FRUniversity Hospital Cologne · DEUniversity of Würzburg · DE

Funding

Disease Mechanisms in Sleep ApneaR01HL065176 · NHLBI · MAYO CLINIC ROCHESTER · PI SOMERS, VIREND K · 1999 to 2021
$5.8M
NHLBI NIH HHS R01 HL065176NHLBI NIH HHS R01HL065176
6 · The paper itself

Abstract

backgroundCentral sleep apnea is associated with poor prognosis and death in patients with heart failure. Adaptive servo-ventilation is a therapy that uses a noninvasive ventilator to treat central sleep apnea by delivering servo-controlled inspiratory pressure support on top of expiratory positive airway pressure. We investigated the effects of adaptive servo-ventilation in patients who had heart failure with reduced ejection fraction and predominantly central sleep apnea.

methodsWe randomly assigned 1325 patients with a left ventricular ejection fraction of 45% or less, an apnea-hypopnea index (AHI) of 15 or more events (occurrences of apnea or hypopnea) per hour, and a predominance of central events to receive guideline-based medical treatment with adaptive servo-ventilation or guideline-based medical treatment alone (control). The primary end point in the time-to-event analysis was the first event of death from any cause, lifesaving cardiovascular intervention (cardiac transplantation, implantation of a ventricular assist device, resuscitation after sudden cardiac arrest, or appropriate lifesaving shock), or unplanned hospitalization for worsening heart failure.

resultsIn the adaptive servo-ventilation group, the mean AHI at 12 months was 6.6 events per hour. The incidence of the primary end point did not differ significantly between the adaptive servo-ventilation group and the control group (54.1% and 50.8%, respectively; hazard ratio, 1.13; 95% confidence interval [CI], 0.97 to 1.31; P=0.10). All-cause mortality and cardiovascular mortality were significantly higher in the adaptive servo-ventilation group than in the control group (hazard ratio for death from any cause, 1.28; 95% CI, 1.06 to 1.55; P=0.01; and hazard ratio for cardiovascular death, 1.34; 95% CI, 1.09 to 1.65; P=0.006).

conclusionsAdaptive servo-ventilation had no significant effect on the primary end point in patients who had heart failure with reduced ejection fraction and predominantly central sleep apnea, but all-cause and cardiovascular mortality were both increased with this therapy. (Funded by ResMed and others; SERVE-HF ClinicalTrials.gov number, NCT00733343.).

Indexed as

AgedCardiovascular DiseasesFemaleHeart Failure, SystolicHospitalizationHumansIntention to Treat AnalysisMaleMiddle AgedPositive-Pressure RespirationSleep Apnea, CentralStroke VolumeTreatment Failure

Identifiers

PMID26323938
PMCPMC4779593
OpenAlexW2198264409

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.