ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2015
Exploring microbial dark matter to resolve the deep archaeal ancestry of eukaryotes.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Exploring Microbial Dark Matter for the Discovery of Novel Natural Products: Characteristics, Abundance Challenges and Methods.Journal of microbiology and biotechnology · 2024Review
- Article
- Proteotyping Environmental Microorganisms by Phylopeptidomics: Case Study Screening Water from a Radioactive Material Storage Pool.Microorganisms · 2020Article
- Article
- Multiple levels of the unknown in microbiome research.BMC biology · 2019Article
- Identification of new members of alkaliphilic lipases in archaea and metagenome database using reconstruction of ancestral sequences.3 Biotech · 2019Article
- Genomic diversity, lifestyles and evolutionary origins of DPANN archaea.FEMS microbiology letters · 2019Review
- Genomes of two archaeal endosymbionts show convergent adaptations to an intracellular lifestyle.The ISME journal · 2018Article
- Microbial Dark Matter Investigations: How Microbial Studies Transform Biological Knowledge and Empirically Sketch a Logic of Scientific Discovery.Genome biology and evolution · 2018Article
- Cultivation and Genomic Analysis of "Frontiers in microbiology · 2018Article
- S-plot2: Rapid Visual and Statistical Analysis of Genomic Sequences.Evolutionary bioinformatics online · 2018Article
- Archaea and the origin of eukaryotes.Nature reviews. Microbiology · 2017Review
- The Physiology of Phagocytosis in the Context of Mitochondrial Origin.Microbiology and molecular biology reviews : MMBR · 2017Review
- Integrative modeling of gene and genome evolution roots the archaeal tree of life.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
- Accessing the genomic information of unculturable oceanic picoeukaryotes by combining multiple single cells.Scientific reports · 2017Article
- Article
- Microbial Community Response to Simulated Petroleum Seepage in Caspian Sea Sediments.Frontiers in microbiology · 2017Article
- Genomic inference of the metabolism of cosmopolitan subsurface Archaea, Hadesarchaea.Nature microbiology · 2016Article
- Birth of Archaeal Cells: Molecular Phylogenetic Analyses of G1P Dehydrogenase, G3P Dehydrogenases, and Glycerol Kinase Suggest Derived Features of Archaeal Membranes Having G1P Polar Lipids.Archaea (Vancouver, B.C.) · 2016Article
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11 authors.
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Abstract
The origin of eukaryotes represents an enigmatic puzzle, which is still lacking a number of essential pieces. Whereas it is currently accepted that the process of eukaryogenesis involved an interplay between a host cell and an alphaproteobacterial endosymbiont, we currently lack detailed information regarding the identity and nature of these players. A number of studies have provided increasing support for the emergence of the eukaryotic host cell from within the archaeal domain of life, displaying a specific affiliation with the archaeal TACK superphylum. Recent studies have shown that genomic exploration of yet-uncultivated archaea, the so-called archaeal 'dark matter', is able to provide unprecedented insights into the process of eukaryogenesis. Here, we provide an overview of state-of-the-art cultivation-independent approaches, and demonstrate how these methods were used to obtain draft genome sequences of several novel members of the TACK superphylum, including Lokiarchaeum, two representatives of the Miscellaneous Crenarchaeotal Group (Bathyarchaeota), and a Korarchaeum-related lineage. The maturation of cultivation-independent genomics approaches, as well as future developments in next-generation sequencing technologies, will revolutionize our current view of microbial evolution and diversity, and provide profound new insights into the early evolution of life, including the enigmatic origin of the eukaryotic cell.
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