Evidence map›Paper›PMID 26323657›Full record

ArticleThe Journal of steroid biochemistry and molecular biology2016

The vitamin D receptor functions as a transcription regulator in the absence of 1,25-dihydroxyvitamin D

Seong Min Lee, J Wesley Pike

Open access · greenAbstract read
In one paragraph

Article in The Journal of steroid biochemistry and molecular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Nuclear hormone receptors in demyelinating diseases.Journal of neuroendocrinology · 2022
    Review
  10. Article
  11. Review
  12. Article
  13. Analysis of 1,25-Dihydroxyvitamin DMolecular and cellular biology · 2020
    Article
  14. Review
  15. Article
  16. Review
  17. The impact of VDR expression and regulation in vivo.The Journal of steroid biochemistry and molecular biology · 2018
    Article
  18. Adipose tissue inflammation andClinical epigenetics · 2018
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Seong Min LeeDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, United States. Electronic address: smlee4@wisc.edu.
J Wesley PikeDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, United States.
University of Wisconsin–Madison · US

Funding

BONE CELL REGULATION OF THE VITAMIN D RECEPTOR GENER01AR045173 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI PIKE, J WESLEY · 1999 to 2015
$3.5M
Dynamic Mechanisms of Vitamin D-Induced Gene ExpressionR01DK072281 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI PIKE, J WESLEY · 2005 to 2012
$2.6M
Vitamin D Ligands and Regulation of Calcium HomeostasisR01DK073995 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI PIKE, J WESLEY · 2008 to 2012
$1.5M
NIAMS NIH HHS R01 AR045173NIDDK NIH HHS R01 DK072281NIDDK NIH HHS R01 DK073995
6 · The paper itself

Abstract

The vitamin D receptor (VDR) is a critical mediator of the biological actions of 1,25-dihydroxyvitamin D

Indexed as

Transcription, Genetic25-Hydroxyvitamin D3 1-alpha-HydroxylaseAnimalsBone and BonesCalcitriolDisease Models, AnimalGene Expression RegulationHairHumansMiceMice, KnockoutParathyroid HormoneReceptors, CalcitriolRickets, HypophosphatemicSignal Transduction25-Hydroxyvitamin D3 1-alpha-HydroxylaseCalcitriolParathyroid HormoneReceptors, Calcitriol1,25-Dihydroxyvitamin D(3)-independent actionCyp27b1 null miceTranscriptional de-repressorTranscription repressorVDR null mice

Identifiers

PMID26323657
PMCPMC4769962
OpenAlexW1569138725

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.