ReviewBMC musculoskeletal disorders2015
Association between work-related biomechanical risk factors and the occurrence of carpal tunnel syndrome: an overview of systematic reviews and a meta-analysis of current research.
Review in BMC musculoskeletal disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 64 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Carpal Tunnel Release Under Local Anaesthesia With or Without Distal Median Nerve Block - a Protocol of a Double Blinded Randomised Controlled Trial
Effect of Fascial Mobilization Therapy on Pain, Grip Strength and Manual Dexterity in Patients With Postpartum Carpal Tunnel Syndrome
Who cites it
64 citing papers in PubMed, 2 syntheses or guidelines pooled it, 139 citations in OpenAlex.
- Injection therapy for carpal tunnel syndrome: A systematic review and network meta-analysis of randomized controlled trials.PloS one · 2024Pooled it
- Psychosocial Risk Factors and the Association With Carpal Tunnel Syndrome: A Systematic Review.Hand (New York, N.Y.) · 2018Pooled it
- The effectiveness of the median nerve neurodynamic mobilisation techniques in women with mild or moderate bilateral carpal tunnel syndrome: A single-blind clinical randomised trial.The South African journal of physiotherapy · 2022Trial
- Carpal tunnel syndrome and exposure to work-related biomechanical stressors and chemicals: Findings from the Constances cohort.PloS one · 2020Trial
- Performance of Handwriting and Digital Typing After Carpal Tunnel Release: The TACTUS (Typing Ability in Carpal Tunnel Syndrome) Study.Journal of functional morphology and kinesiology · 2026Article
- Effects of white cane handle angle and technique on upper limb biomechanics and comfort in visually impaired users.Scientific reports · 2026Article
- The Silent Strain: Grip Strength, and Wrist/Hand Musculoskeletal Disorders among Meat Cutters.La Medicina del lavoro · 2026Article
- Occupational biomechanical risk factors for carpal tunnel syndrome surgery: a prospective cohort study on 203 866 Swedish male construction workers followed for 19 years.Occupational and environmental medicine · 2025Article
- Computer Use and Compressive Neuropathies of the Upper Limbs: A Hidden Risk?Journal of clinical medicine · 2025Review
- Occupational nerve injuries.Muscle & nerve · 2025Review
- Reliability and Accuracy of Standard Reference Procedures for Measurements of Trunk and Arm Postures in Ergonomics.Bioengineering (Basel, Switzerland) · 2025Article
- Article
- Sex-differences in the risk of carpal tunnel syndrome: results from a large Ontario, Canada worker cohort.BMC musculoskeletal disorders · 2024Article
- Effectiveness of Sensors-Based Augmented Feedback in Ergonomics to Reduce Adverse Biomechanical Exposure in Work-Related Manual Handling-A Rapid Review of the Evidence.Sensors (Basel, Switzerland) · 2024Review
- Comparison of Effects of Ultrasound Therapy and Nerve-Gliding Techniques on Patients with Carpal Tunnel Syndrome: A Randomized Clinical Trial.Anesthesiology and pain medicine · 2024Article
- A Rapid Review on the Effectiveness and Use of Wearable Biofeedback Motion Capture Systems in Ergonomics to Mitigate Adverse Postures and Movements of the Upper Body.Sensors (Basel, Switzerland) · 2024Review
- Hand and wrist complaints in dialysis nurses in Germany: a survey of prevalence, severity, and occupational associations.Annals of work exposures and health · 2024Article
- Musculoskeletal complaints, physical work demands, and functional capacity in individuals with a brachial plexus injury: An exploratory study.Work (Reading, Mass.) · 2024Article
- Prevalence of carpal tunnel syndrome symptoms among neurosurgical spine surgeons.World neurosurgery: X · 2024Article
- Development and validation of a work-related risk score for upper-extremity musculoskeletal disorders in a French working population.Scandinavian journal of work, environment & health · 2023Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOccupational risks for carpal tunnel syndrome (CTS) have been examined in various occupations, and several systematic reviews (SRs) have been published on this topic. There has been no critical appraisal or synthesis of the evidence in the SRs. The aims of this study are (1) to synthesise the observational evidence and evaluate the methodological quality of SRs that assess the effect of biomechanical risk factors on the development of CTS in workers, (2) to provide an update of current primary research on this association, (3) to assess a potential dose-response relationship.
methodsWe searched MEDLINE, EMBASE, CINAHL, the Cochrane Library and the reference lists of articles. The first step covered SRs (1998-2014), and the second step covered current primary studies (2011-2014). The methodological quality of the SRs was evaluated by using the AMSTAR-R tool; primary studies were assessed using a list of 20 items. A qualitative approach was used for synthesising evidence. In addition, we undertook a meta-analysis of the primary studies to determine risk ratios in the dose-response relationship.
resultsWe identified ten SRs that covered a total of 143 original studies. Seven primary studies met the criteria for inclusion, of which four provided longitudinal data. We found high quality of evidence for risk factors such as repetition, force and combined exposures. Moderate quality of evidence was observed for vibration, and low quality of evidence was found for wrist postures. An association between computer use and CTS could not be established. Recent primary studies supported the existence of a significant relationship between CTS and repetition, force and combined exposure. The meta-analysis of current research revealed a dose-response relationship between CTS and the American Conference of Governmental Industrial Hygienists' (ACGIH) threshold limit value (TLV) for hand-activity level (HAL). Those between the action limit and TLV and above TLV had RR of 1.5 (95% CI 1.02-2.31) and RR 2.0 (95% CI 1.46-2.82), respectively.
conclusionsOccupational biomechanical factors play a substantial role in the causation of CTS. Data from current primary studies on dose-response suggest that the risk of CTS increases with the ACGIH TLV levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.