Evidence map›Paper›PMID 26323631›Full record

ReviewILAR journal2015

Xenobiotics: Interaction with the Intestinal Microflora.

Kun Lu, Ridwan Mahbub, James G Fox

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in ILAR journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 110 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. The roles of ABCB1/P-glycoprotein drug transporters in regulating gut microbes and inflammation: insights from animal models, old and new.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
  7. Review
  8. Article
  9. Nutrients · 2023
    Article
  10. Review
  11. Anti-cancer activity of human gastrointestinal bacteria.Medical oncology (Northwood, London, England) · 2022
    Review
  12. The Microbiota-Gut-Brain Axis in Psychiatric Disorders.International journal of molecular sciences · 2022
    Review
  13. Article
  14. Review
  15. Development of anFrontiers in microbiology · 2022
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kun LuKun Lu, PhD, is an Assistant Professor in the Department of Environmental Health Science at the University of Georgia, Athens, Georgia. Ridwan Mahbub, BSA, MS, was a graduate student in the laboratory of Dr. Kun Lu at University of Georgia, Athens, Georgia. James G. Fox, DVM, is currently Professor and Director of the Division of Comparative Medicine at the Massachusetts Institute of Technology, Cambridge, Massachusetts.
Ridwan MahbubKun Lu, PhD, is an Assistant Professor in the Department of Environmental Health Science at the University of Georgia, Athens, Georgia. Ridwan Mahbub, BSA, MS, was a graduate student in the laboratory of Dr. Kun Lu at University of Georgia, Athens, Georgia. James G. Fox, DVM, is currently Professor and Director of the Division of Comparative Medicine at the Massachusetts Institute of Technology, Cambridge, Massachusetts.
James G FoxKun Lu, PhD, is an Assistant Professor in the Department of Environmental Health Science at the University of Georgia, Athens, Georgia. Ridwan Mahbub, BSA, MS, was a graduate student in the laboratory of Dr. Kun Lu at University of Georgia, Athens, Georgia. James G. Fox, DVM, is currently Professor and Director of the Division of Comparative Medicine at the Massachusetts Institute of Technology, Cambridge, Massachusetts.
Massachusetts Institute of Technology · US

Funding

TOXICOLOGY CORE UNITP30ES002109 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LEVINE, STUART S · 1985 to 2020
$25.6M
Functional interaction between the gut microbiome and arsenic exposureR01ES024950 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LU, KUN · 2015 to 2019
$2.5M
NIEHS NIH HHS ES024950NIEHS NIH HHS P30 ES002109NIEHS NIH HHS R01 ES024950
6 · The paper itself

Abstract

The human body is host to 100 trillion gut microbes, approximately 10-times more than all human cells. It is estimated that the approximately 500-1000 species residing in the human gut encode 150-fold more unique genes than the human genome. The gut microbiota has important functions in metabolic processing, such as energy production, immune cell development, food digestion, and epithelial homeostasis. It has been increasingly recognized that a dysregulated gut microbiome contributes in a significant way to a variety of diseases, including diabetes, obesity, cardiovascular diseases, allergies, and inflammatory bowel disease. In particular, accumulating evidence indicates that functional interactions between the gut microbiome and xenobiotics play a role in mediating chemical toxicity and causing or exacerbating human disease. This review summarizes emerging evidence that illustrates how xenobiotics can affect the gut microbiome structure, create functional changes to the gut microbiome, and become biotransformed by the gut microbiome.

Indexed as

AnimalsGastrointestinal MicrobiomeHumansXenobioticsXenobioticsgut microbiomeinteractionxenobiotics

Identifiers

PMID26323631
PMCPMC4654756
OpenAlexW1938579688

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.