Evidence map›Paper›PMID 26323608›Full record

ArticleNeuro-oncology2016

Long-term outcomes and prognostic factors of skull-base chondrosarcoma patients treated with pencil-beam scanning proton therapy at the Paul Scherrer Institute.

Damien C Weber, Shahed Badiyan, Robert Malyapa, Francesca Albertini, Alessandra Bolsi, Antony J Lomax, Ralf Schneider

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuro-oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Review
  4. Article
  5. Review
  6. [Clinical analysis of endoscopic transnasal resection of skull base chondrosarcoma].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024
    Article
  7. Review
  8. Article
  9. Proton Therapy for Skull Base Chondrosarcoma.Journal of neurological surgery reports · 2023
    Article
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  12. Article
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  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Damien C WeberCenter for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland (D.C.W., S.B., R.M., F.A., A.B., A.J.L, R.S.); University of Bern, Bern, Switxerland (D.C.W.); University of Zürich, Zürich, Switzerland (D.C.W.); Department of Physics, ETH, Zürich, Switzerland (A.J.L.).
Shahed BadiyanCenter for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland (D.C.W., S.B., R.M., F.A., A.B., A.J.L, R.S.); University of Bern, Bern, Switxerland (D.C.W.); University of Zürich, Zürich, Switzerland (D.C.W.); Department of Physics, ETH, Zürich, Switzerland (A.J.L.).
Robert MalyapaCenter for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland (D.C.W., S.B., R.M., F.A., A.B., A.J.L, R.S.); University of Bern, Bern, Switxerland (D.C.W.); University of Zürich, Zürich, Switzerland (D.C.W.); Department of Physics, ETH, Zürich, Switzerland (A.J.L.).
Francesca AlbertiniCenter for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland (D.C.W., S.B., R.M., F.A., A.B., A.J.L, R.S.); University of Bern, Bern, Switxerland (D.C.W.); University of Zürich, Zürich, Switzerland (D.C.W.); Department of Physics, ETH, Zürich, Switzerland (A.J.L.).
Alessandra BolsiCenter for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland (D.C.W., S.B., R.M., F.A., A.B., A.J.L, R.S.); University of Bern, Bern, Switxerland (D.C.W.); University of Zürich, Zürich, Switzerland (D.C.W.); Department of Physics, ETH, Zürich, Switzerland (A.J.L.).
Antony J LomaxCenter for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland (D.C.W., S.B., R.M., F.A., A.B., A.J.L, R.S.); University of Bern, Bern, Switxerland (D.C.W.); University of Zürich, Zürich, Switzerland (D.C.W.); Department of Physics, ETH, Zürich, Switzerland (A.J.L.).
Ralf SchneiderCenter for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland (D.C.W., S.B., R.M., F.A., A.B., A.J.L, R.S.); University of Bern, Bern, Switxerland (D.C.W.); University of Zürich, Zürich, Switzerland (D.C.W.); Department of Physics, ETH, Zürich, Switzerland (A.J.L.).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSkull-base chondrosarcoma (ChSa) is a rare disease, and the prognostication of this disease entity is ill defined.

methodsWe assessed the long-term local control (LC) results, overall survival (OS), and prognostic factors of skull-base ChSa patients treated with pencil beam scanning proton therapy (PBS PT). Seventy-seven (male, 35; 46%) patients with histologically confirmed ChSa were treated at the Paul Scherrer Institute. Median age was 38.9 years (range, 10.2-70.0y). Median delivered dose was 70.0 GyRBE (range, 64.0-76.0 GyRBE). LC, OS, and toxicity-free survival (TFS) rates were calculated using the Kaplan Meier method.

resultsAfter a mean follow-up of 69.2 months (range, 4.6-190.8 mo), 6 local (7.8%) failures were observed, 2 of which were late failures. Five (6.5%) patients died. The actuarial 8-year LC and OS were 89.7% and 93.5%, respectively. Tumor volume > 25 cm(3) (P = .02), brainstem/optic apparatus compression at the time of PT (P = .04) and age >30 years (P = .08) were associated with lower rates of LC. High-grade (≥3) radiation-induced toxicity was observed in 6 (7.8%) patients. The 8-year high-grade TFS was 90.8%. A higher rate of high-grade toxicity was observed for older patients (P = .073), those with larger tumor volume (P = .069), and those treated with 5 weekly fractions (P = .069).

conclusionsThis is the largest PT series reporting the outcome of patients with low-grade ChSa of the skull base treated with PBS only. Our data indicate that protons are both safe and effective. Tumor volume, brainstem/optic apparatus compression, and age were prognosticators of local failures.

Indexed as

Proton TherapyAdolescentAdultAgedBone NeoplasmsChildChondrosarcomaFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoplasm GradingPrognosisRadiotherapy DosageSkull Base Neoplasmschondrosarcomapencil beam scanningprognostic factorsproton therapyskull-base tumors

Identifiers

PMID26323608
PMCPMC4724177

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.