Evidence map›Paper›PMID 26323330›Full record

Observational studyOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2016

Increased sclerostin and preadipocyte factor-1 levels in prepubertal rhythmic gymnasts: associations with bone mineral density, body composition, and adipocytokine values.

J Jürimäe, V Tillmann, A Cicchella, C Stefanelli, K Võsoberg, A L Tamm, T Jürimäe

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Trial
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  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Exercise Early and Often: Effects of Physical Activity and Exercise on Women's Bone Health.International journal of environmental research and public health · 2018
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

J JürimäeInstitute of Sport Pedagogy and Coaching Sciences, Faculty of Exercise and Sport Sciences, University of Tartu, Tartu, Estonia. jaak.jurimae@ut.ee.
V TillmannDepartment of Pediatrics, Faculty of Medicine, University of Tartu, Tartu, Estonia.
A CicchellaDepartment of Sciences for Quality of Life, University of Bologna, Bologna, Italy.
C StefanelliDepartment of Sciences for Quality of Life, University of Bologna, Bologna, Italy.
K VõsobergInstitute of Sport Pedagogy and Coaching Sciences, Faculty of Exercise and Sport Sciences, University of Tartu, Tartu, Estonia.
A L TammTartu Health Care College, Tartu, Estonia.
T JürimäeInstitute of Sport Pedagogy and Coaching Sciences, Faculty of Exercise and Sport Sciences, University of Tartu, Tartu, Estonia.
University of Tartu · EEUniversity of Bologna · ITTartu Health Care College · EE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

summaryRhythmic gymnastics as high-impact bone loading sport has positive effects on bone mineralization in prepubertal years. Sclerostin and preadipocyte factor-1 (Pref-1) are hormones that inhibit bone formation. The present study demonstrates that these hormones are higher in gymnasts, and gymnasts present higher bone mineral density (BMD) as compared to controls.

introductionRhythmic gymnasts (RG) start their heavy trainings already in prepuberty and despite of low body fat mass (FM) and hypoleptinemia, their BMD is higher than in non-trained normal girls. The specific role of sclerostin and Pref-1, which are the inhibitors of bone formation, in bone development is not well understood. The impact of sclerostin and Pref-1 levels on BMD, body composition, and adipocytokine values was studied in prepubertal RG and untrained controls (UC).

methodsSixty-four 9-10-year-old girls were divided into RG (n = 32) and UC (n = 32) groups. Bone mineral and body composition values were measured by dual-energy X-ray absorptiometry and bone age by X-ray. Sclerostin, Pref-1, leptin, and adiponectin levels were measured from fasting blood samples.

resultsSclerostin (RG 19.8 ± 6.3 pmol/l; UC 15.8 ± 5.4 pmol/l) and Pref-1 (RG 1.6 ± 1.0 ng/ml; UC 1.1 ± 0.5 ng/ml) were higher (p < 0.05) in RG compared with UC. Sclerostin was related to adiponectin (r = 0.41; p < 0.05) in UC. No relationship was found between sclerostin and Pref-1 with BMD values in prepubertal RG and age-matched UC groups.

conclusionsSclerostin and Pref-1 levels are higher in RG compared to UC girls. Specific physical activity pattern seen in prepubertal RG has a beneficial effect on bone mineralization despite increased levels of hormones that inhibit bone formation.

Indexed as

Absorptiometry, PhotonAdaptor Proteins, Signal TransducingAdipokinesBiomarkersBody CompositionBone DensityBone Morphogenetic ProteinsCalcium-Binding ProteinsCase-Control StudiesChildFemaleGenetic MarkersGymnasticsHumansIntercellular Signaling Peptides and ProteinsMembrane ProteinsAdaptor Proteins, Signal TransducingAdipokinesBiomarkersBone Morphogenetic ProteinsCalcium-Binding ProteinsDLK1 protein, humanGenetic MarkersIntercellular Signaling Peptides and ProteinsMembrane ProteinsSOST protein, humanAdiponectinBone mineral densityLeptinPref-1Prepubertal athletesSclerostin

Identifiers

PMID26323330
OpenAlexW1226803000

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.