Evidence map›Paper›PMID 26323259›Full record

ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2016

Prognostic values of Notch receptors in breast cancer.

Junming Xu, Fangbin Song, Tao Jin, Jun Qin, Junyi Wu, Min Wang, Ye Wang, Jun Liu

Abstract read
PubMed Publisher
In one paragraph

Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
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  11. Association between single nucleotide polymorphisms ofCancer management and research · 2019
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  14. [MiR-433 reverses chemoresistance to docetaxel by targeting Notch1 in breast cancer cells].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Junming XuDepartment of General Surgery, Shanghai First People's Hospital, Shanghai Jiaotong University, 100 Haining Road, Shanghai, People's Republic of China, 200080. Junmingxu@hotmail.com.
Fangbin SongDepartment of General Surgery, Shanghai First People's Hospital, Shanghai Jiaotong University, 100 Haining Road, Shanghai, People's Republic of China, 200080.
Tao JinDepartment of General Surgery, Shanghai First People's Hospital, Shanghai Jiaotong University, 100 Haining Road, Shanghai, People's Republic of China, 200080.
Jun QinDepartment of General Surgery, Shanghai First People's Hospital, Shanghai Jiaotong University, 100 Haining Road, Shanghai, People's Republic of China, 200080.
Junyi WuDepartment of General Surgery, Shanghai First People's Hospital, Shanghai Jiaotong University, 100 Haining Road, Shanghai, People's Republic of China, 200080.
Min WangDepartment of General Surgery, Shanghai First People's Hospital, Shanghai Jiaotong University, 100 Haining Road, Shanghai, People's Republic of China, 200080.
Ye WangDepartment of General Surgery, Shanghai First People's Hospital, Shanghai Jiaotong University, 100 Haining Road, Shanghai, People's Republic of China, 200080.
Jun LiuDepartment of General Surgery, Shanghai First People's Hospital, Shanghai Jiaotong University, 100 Haining Road, Shanghai, People's Republic of China, 200080.
Shanghai First People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Notch receptors are frequently deregulated in several human malignancies including human breast cancer. Activation of Notch has been reported to cause mammary carcinomas in mice. However, the prognostic value of individual Notch receptors in breast cancer (BC) patients remains elusive. In the current study, we investigated the prognostic value of Notch receptors in human BC patients. More specifically, we investigated the prognostic value of four Notch receptors in breast cancer patients through "the Kaplan-Meier plotter" (KM plotter) database, in which updated gene expression data and survival information are from a total of 3554 breast cancer patients. Our results showed that Notch1 messenger RNA (mRNA) high expression was correlated to worsen overall survival (OS) in PgR-negative BC patients. Notch2, Notch3, and Notch4 mRNA high expressions were found to be correlated to better OS for all breast cancer patients. Notch2 was also found to be correlated to better OS in lymph node-negative breast cancer patients and HER2-positive breast cancer patients. These results will be useful for better understanding of the heterogeneity and complexity in the molecular biology of breast cancer and for developing tools to more accurately predict their prognosis and design their customized treatment strategies.

Indexed as

Breast NeoplasmsErb-b2 Receptor Tyrosine KinasesFemaleGene Expression Regulation, NeoplasticHumansKaplan-Meier EstimatePrognosisReceptors, EstrogenReceptors, NotchReceptors, ProgesteroneRNA, MessengerErb-b2 Receptor Tyrosine KinasesReceptors, EstrogenReceptors, NotchReceptors, ProgesteroneRNA, MessengerEstrogen receptor (ER)Hazardous ratio (HR)KM plotterNotch receptorPrognosis

Identifiers

PMID26323259
OpenAlexW1816419236

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.