Observational studyThe American journal of gastroenterology2015
Elevated serum triglycerides are independently associated with persistent organ failure in acute pancreatitis.
Observational study in The American journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers, 8 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
143 citing papers in PubMed, 8 syntheses or guidelines pooled it, 288 citations in OpenAlex.
- Efficacy of Olezarsen in Severe Hypertriglyceridemia and Acute Pancreatitis Risk: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Digestive diseases and sciences · 2026Pooled it
- Efficacy and safety of small interfering RNA (siRNA) therapies for hypertriglyceridemia and mixed dyslipidemia: an updated systematic review and meta-analysis.Frontiers in pharmacology · 2026Pooled it
- Global burden and characterization of hypertriglyceridemia-induced acute pancreatitis: results from a systematic review and a multi-center cohort study.Science China. Life sciences · 2025Pooled it
- A systematic review of the epidemiology and risk factors for severity and recurrence of hypertriglyceridemia-induced acute pancreatitis.BMC gastroenterology · 2025Pooled it
- Metabolic syndrome components individually worsen the outcome of acute pancreatitis: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Alteration of Peripheral Resistin and the Severity of Acute Pancreatitis: A Meta-Analysis.Frontiers in medicine · 2022Pooled it
- Assessment of the course of acute pancreatitis in the light of aetiology: a systematic review and meta-analysis.Scientific reports · 2020Pooled it
- The effect of serum triglyceride concentration on the outcome of acute pancreatitis: systematic review and meta-analysis.Scientific reports · 2018Pooled it
- Randomized controlled trial: neostigmine for intra-abdominal hypertension in acute pancreatitis.Critical care (London, England) · 2022Trial
- Effects of Abnormal Lipid Metabolism on Pancreatic Injury and Ferroptosis-Related Indicators in Rats with Severe Acute Pancreatitis.Digestive diseases and sciences · 2026Article
- Multiple organ dysfunction syndrome: molecular mechanisms and therapeutic strategies.Signal transduction and targeted therapy · 2026Review
- Hypertriglyceridaemia-Associated Acute Pancreatitis: Pathophysiological Insights and Advances in Clinical Management.Biomedicines · 2026Review
- Hypertriglyceridemia‑Induced Acute Pancreatitis Compared With Non-Hypertriglyceridemia Acute Pancreatitis: A Retrospective Case-Control Study.Health science reports · 2026Article
- Successful treatment with plasmapheresis of severe hypertriglyceridemic acute pancreatitis complicated by fat overload syndrome caused by lipid injectable emulsion: a case report and review of the literature.Journal of medical case reports · 2026Review
- PVNJournal of neuroinflammation · 2026Article
- Prompt cesarean delivery in late pregnancy for hyperlipidemia-induced pancreatitis: a case report.Clinical journal of gastroenterology · 2026Article
- Hypertriglyceridemia Screening in Acute Pancreatitis: Diagnostic Blind Spot in Clinical Routine.Digestive diseases and sciences · 2026Article
- Acute pancreatitis: mechanisms and therapeutic approaches.Signal transduction and targeted therapy · 2026Review
- Risk factors for disease severity in hypertriglyceridemic acute pancreatitis: a single-center retrospective study.BMC gastroenterology · 2026Article
- Potential influence of gut microbiota on the process of hypertriglyceridemia-aggravated acute pancreatitis.World journal of gastroenterology · 2026Review
83 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesHypertriglyceridemia (HTG) represents a major health problem with prevalence exceeding 30% in the U.S. The present study aims to assess the effect of elevated serum triglyceride (TG) levels on the severity of acute pancreatitis (AP).
methodsProspectively enrolled AP patients were categorized into normal, mild, moderate, and severe/very severe categories based on their TG levels and compared in respect to demographics, comorbidities, and clinical outcomes. Multivariate analysis determined whether elevated TG levels were independently associated with persistent organ failure.
resultsTwo hundred and one out of 400 AP patients had serum TGs measured within 72 h of presentation, of which 115 had normal TG levels and 86 HTG (20 mild, 41 moderate, and 25 severe/very severe). Patients with HTG were of younger age (44 vs. 52 years), predominantly male (65% vs. 45%), obese (57% vs. 34%), diabetic (38% vs. 17%), and developed more frequently persistent organ failure (40% vs. 17%) compared with those with normal TGs (P<0.02). The rate of persistent organ failure increased proportionally with HTG severity grades (17% when normal TGs, 30% in mild, 39% in moderate, and 48% in severe/very severe HTG, Ptrend<0.001). On multivariate analysis controlling for age, gender, body mass index, diabetes, and alcohol etiology, moderate HTG (odds ratio (OR), 2.6; P=0.04) and severe/very severe HTG (OR, 4.9; P=0.009) were independently associated with persistent organ failure.
conclusionsElevated serum TGs in AP patients are independently and proportionally correlated with persistent organ failure regardless of etiology. TG-mediated lipotoxicity may be an attractive target to design novel interventions for severe AP.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.