Evidence map›Paper›PMID 26323070›Full record

ArticleKidney international2015

IgM in the kidney: a multiple personality disorder.

Jeffrey L Platt, Marilia Cascalho

Abstract readComment
In one paragraph

Article in Kidney international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Review
  9. Article
  10. The five dimensions of B cell tolerance.Immunological reviews · 2019
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Jeffrey L PlattDepartment of Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Marilia CascalhoDepartment of Surgery, University of Michigan, Ann Arbor, Michigan, USA.

Funding

Xenogeneic Natural Antibody Targets-Structure/FunctionR37HL052297 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PLATT, JEFFREY L · 2001 to 2010
$3.9M
Heparan Sulfate-TLR in Health, Injury and ImmunityR01AI053733 · NIAID · MAYO CLINIC ROCHESTER · PI PLATT, JEFFREY L · 2003 to 2007
$1.6M
NHLBI NIH HHS R37 HL052297NIAID NIH HHS R01 AI053733
6 · The paper itself

Abstract

IgM in the blood of normal individuals consists mainly of 'natural' polyreactive antibodies. Natural IgM is thought to provide an initial defense against infection and to promote the healing of wounded cells. Yet, as Panzer and colleagues show, these benefits can be eclipsed when the IgM binds to damaged cells of the glomerulus, activating complement. IgM in glomeruli thus signifies cellular damage and may warn that the pace of that damage exceeds the capacity for repair.

Indexed as

Complement ActivationAnimalsComplement Factor HGlomerulonephritisImmunoglobulin MKidney GlomerulusMaleComplement Factor HImmunoglobulin M

Identifiers

PMID26323070
PMCPMC4556166

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.