ArticleNature neuroscience2015
Large-scale transcriptional profiling of chemosensory neurons identifies receptor-ligand pairs in vivo.
Article in Nature neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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Who cites it
85 citing papers in PubMed.
- Article
- Genome and transcriptome-based identification and expression profiling of chemosensory gene families across developmental stages and tissues in Sirex noctilio (Hymenoptera: Siricidae).Insect molecular biology · 2026Article
- Article
- Intrinsic Diversity in Odor-Evoked Calcium Rises acrossThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Understanding the Chemosensory and Detoxification Mechanisms in the Oriental Fruit Fly,Insects · 2026Article
- Receptor sequence divergence, gain, loss, duplication, and neofunctionalization drive olfactory adaptation inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- The Odorant-Binding Proteins AspiOBP1 and AspiOBP2 inInternational journal of molecular sciences · 2025Article
- Environmental stress promotes the persistence of juvenile traits in olfactory neurons as a protective mechanism.iScience · 2025Article
- New dimensions in the molecular genetics of insect chemoreception.Trends in genetics : TIG · 2025Review
- Impact of elevated COScientific reports · 2025Article
- Methyl eugenol regulates mating behavior in oriental fruit flies by enhancing lek attractiveness.National science review · 2025Article
- Determinants of odorant receptor transcription and gene choice.Chemical senses · 2025Review
- Distinct odorant receptor response patterns to aliphatic odorants in freely behaving mice.Chemical senses · 2025Article
- Constancy of olfactory cilia in rodents.Chemical senses · 2025Article
- Electroantennographic response and odorant-binding protein expression alterations induced by host plant volatiles inFrontiers in physiology · 2025Article
- Identification of Olfactory Receptors Responding to Androstenone and the Key Structure Determinant in Domestic Pig.Current issues in molecular biology · 2024Article
- Perceptual constancy for an odor is acquired through changes in primary sensory neurons.Science advances · 2024Article
- Development of an rpS6-Based Ex Vivo Assay for the Analysis of Neuronal Activity in Mouse and Human Olfactory Systems.International journal of molecular sciences · 2024Article
- Targeting Odorant Receptors in Adipose Tissue with Food-Derived Odorants: A Novel Approach to Obesity Treatment.Foods (Basel, Switzerland) · 2024Review
25 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In mammals, olfactory perception is based on the combinatorial activation of G protein-coupled receptors. Identifying the full repertoire of receptors activated by a given odorant in vivo, a quest that has been hampered for over 20 years by technical difficulties, would represent an important step in deciphering the rules governing chemoperception. We found that odorants induced a fast and reversible concentration-dependent decrease in the transcription of genes corresponding to activated receptors in intact mice. On the basis of this finding, we developed a large-scale transcriptomic approach to uncover receptor-ligand pairs in vivo. We identified the mouse and rat odorant receptor signatures corresponding to specific odorants. Finally, we found that this approach, which can be used for species for which no genomic sequence is available, is also applicable to non-vertebrate species such as Drosophila.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.