ArticleNature cell biology2015
Lipid signalling couples translational surveillance to systemic detoxification in Caenorhabditis elegans.
Article in Nature cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Interplay between proteostasis pathways and innate immune responses inInfection and immunity · 2026Review
- Early life starvation and Hedgehog-related signaling activate innate immunity downstream of daf-18/PTEN and lin-35/Rb causing developmental pathology in adult C. elegans.PLoS genetics · 2025Article
- Biological and clinical implications of a model of surveillance immunity.The Journal of clinical investigation · 2025Review
- Translation elongation defects activate theProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Analysis ofComputational and structural biotechnology journal · 2024Article
- Article
- The lipidomes ofAging · 2023Article
- Novel Immune Modulators EnhancemSphere · 2021Article
- Mitochondrial dysfunction induces RNA interference in C. elegans through a pathway homologous to the mammalian RIG-I antiviral response.PLoS biology · 2020Article
- Pseudomonas aeruginosa cleaves the decoding center of Caenorhabditis elegans ribosomes.PLoS biology · 2020Article
- ROS-based lethality ofProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Mitochondrial Dysfunction in C. elegans Activates Mitochondrial Relocalization and Nuclear Hormone Receptor-Dependent Detoxification Genes.Cell metabolism · 2019Article
- Centrosome Loss Triggers a Transcriptional Program To Counter Apoptosis-Induced Oxidative Stress.Genetics · 2019Article
- Both live and dead Enterococci activate Caenorhabditis elegans host defense via immune and stress pathways.Virulence · 2018Article
- Innate immunity mediated longevity and longevity induced by germ cell removal converge on the C-type lectin domain protein IRG-7.PLoS genetics · 2017Article
- Glucose or Altered Ceramide Biosynthesis Mediate Oxygen Deprivation Sensitivity Through Novel Pathways Revealed by Transcriptome Analysis in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2016Article
- Surveillance Immunity: An Emerging Paradigm of Innate Defense Activation in Caenorhabditis elegans.PLoS pathogens · 2016Review
- The Mitochondrial Unfolded Protein Response Protects against Anoxia in Caenorhabditis elegans.PloS one · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Translation in eukaryotes is followed to detect toxins and virulence factors and coupled to the induction of defence pathways. Caenorhabditis elegans germline-specific mutations in translation components are detected by this system to induce detoxification and immune responses in distinct somatic cells. An RNA interference screen revealed gene inactivations that act at multiple steps in lipid biosynthetic and kinase pathways upstream of MAP kinase to mediate the systemic communication of translation defects to induce detoxification genes. Mammalian bile acids can rescue the defect in detoxification gene induction caused by C. elegans lipid biosynthetic gene inactivations. Extracts prepared from C. elegans with translation deficits but not from the wild type can also rescue detoxification gene induction in lipid-biosynthesis-defective strains. These eukaryotic antibacterial countermeasures are not ignored by bacteria: particular bacterial species suppress normal C. elegans detoxification responses to mutations in translation factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.