ArticlePediatric research2015
Neonatal brain microstructure correlates of neurodevelopment and gait in preterm children 18-22 mo of age: an MRI and DTI study.
Article in Pediatric research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Nutrition and the developing brain: the road to optimizing early neurodevelopment: a systematic review.Pediatric research · 2020Pooled it
- Advanced neuroimaging and its role in predicting neurodevelopmental outcomes in very preterm infants.Seminars in perinatology · 2016Pooled it
- Improved brain growth and microstructural development in breast milk-fed very low birth weight premature infants.Acta paediatrica (Oslo, Norway : 1992) · 2020Trial
- Review
- Donor human milk and structural brain development in very preterm infants.Pediatric research · 2026Observational
- Structuro-Functional Differentiation and Coupling of Gyri and Sulci in the Neonatal Cortex.Human brain mapping · 2026Article
- Beyond motor learning: Insights from infant magnetic resonance imaging on the critical role of the cerebellum in behavioral development.Developmental cognitive neuroscience · 2025Review
- Brain development using a multicomponent intravenous lipid emulsion in preterm infants.BMC pediatrics · 2024Article
- Neuromuscular impairments of cerebral palsy: contributions to gait abnormalities and implications for treatment.Frontiers in human neuroscience · 2024Article
- Article
- Altered microstructure of the splenium of corpus callosum is associated with neurodevelopmental impairment in preterm infants with necrotizing enterocolitis.Italian journal of pediatrics · 2022Observational
- The Effects of Preterm Birth on Musculoskeletal Health-Related Disorders.Journal of clinical medicine · 2021Review
- Early micro- and macrostructure of sensorimotor tracts and development of cerebral palsy in high risk infants.Human brain mapping · 2021Article
- Sexual Dimorphisms and Asymmetries of the Thalamo-Cortical Pathways and Subcortical Grey Matter of Term Born Healthy Neonates: An Investigation with Diffusion Tensor MRI.Diagnostics (Basel, Switzerland) · 2021Article
- Delayed Maturation of the Middle Cerebellar Peduncles at Near-Term Age Predicts Abnormal Neurodevelopment in Preterm Infants.Neonatology · 2021Article
- Structural Brain Lesions and Gait Pathology in Children With Spastic Cerebral Palsy.Frontiers in human neuroscience · 2020Article
- Neonatal white matter tract microstructure and 2-year language outcomes after preterm birth.NeuroImage. Clinical · 2020Article
- Neurologic Injury and Brain Growth in the Setting of Long-Gap Esophageal Atresia Perioperative Critical Care: A Pilot Study.Brain sciences · 2019Article
- Quantitative MRI study of infant regional brain size following surgery for long-gap esophageal atresia requiring prolonged critical care.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2019Article
- Early Detection of Cerebral Palsy Using Sensorimotor Tract Biomarkers in Very Preterm Infants.Pediatric neurology · 2019Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundNear-term brain structure was examined in preterm infants in relation to neurodevelopment. We hypothesized that near-term macrostructural brain abnormalities identified using conventional magnetic resonance imaging (MRI), and white matter (WM) microstructure detected using diffusion tensor imaging (DTI), would correlate with lower cognitive and motor development and slower, less-stable gait at 18-22 mo of age.
methodsOne hundred and two very-low-birth-weight preterm infants (≤1,500 g birth weight; ≤32 wk gestational age) were recruited prior to routine near-term brain MRI at 36.6 ± 1.8 wk postmenstrual age. Cerebellar and WM macrostructure was assessed on conventional structural MRI. DTI was obtained in 66 out of 102 and WM microstructure was assessed using fractional anisotropy and mean diffusivity (MD) in six subcortical brain regions defined by DiffeoMap neonatal atlas. Neurodevelopment was assessed with Bayley-Scales-of-Infant-Toddler-Development, 3rd-Edition (BSID-III); gait was assessed using an instrumented mat.
resultsNeonates with cerebellar abnormalities identified using MRI demonstrated lower mean BSID-III cognitive composite scores (89.0 ± 10.1 vs. 97.8 ± 12.4; P = 0.002) at 18-22 mo. Neonates with higher DTI-derived left posterior limb of internal capsule (PLIC) MD demonstrated lower cognitive and motor composite scores (r = -0.368; P = 0.004; r = -0.354; P = 0.006) at 18-22 mo; neonates with higher genu MD demonstrated slower gait velocity (r = -0.374; P = 0.007). Multivariate linear regression significantly predicted cognitive (adjusted r(2) = 0.247; P = 0.002) and motor score (adjusted r(2) = 0.131; P = 0.017).
conclusionNear-term cerebellar macrostructure and PLIC and genu microstructure were predictive of early neurodevelopment and gait.
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