Evidence map›Paper›PMID 26322410›Full record

Trial reportPediatric research2015

Human milk oligosaccharides in premature infants: absorption, excretion, and influence on the intestinal microbiota.

Mark A Underwood, Stephanie Gaerlan, Maria Lorna A De Leoz, Lauren Dimapasoc, Karen M Kalanetra, Danielle G Lemay, J Bruce German, David A Mills, Carlito B Lebrilla

Open access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pediatric research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 6 pooled it
14.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 6 syntheses or guidelines pooled it, 192 citations in OpenAlex.

  1. Pooled it
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38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Mark A UnderwoodDepartment of Pediatrics, University of California Davis, Sacramento, California.
Stephanie GaerlanDepartment of Chemistry, University of California Davis, Davis, California.
Maria Lorna A De LeozDepartment of Chemistry, University of California Davis, Davis, California.
Lauren DimapasocDepartment of Chemistry, University of California Davis, Davis, California.
Karen M KalanetraDepartment of Viticulture and Enology, University of California Davis, Davis, California.
Danielle G LemayGenome Center, University of California Davis, Davis, California.
J Bruce GermanDepartment of Food Science and Technology, University of California Davis, Davis, California.
David A MillsDepartment of Viticulture and Enology, University of California Davis, Davis, California.
Carlito B LebrillaDepartment of Chemistry, University of California Davis, Davis, California.
University of California, Davis · US

Funding

UC Davis Clinical and Translational Science CenterUL1TR000002 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERGLUND, LARS F · 2012 to 2015
$12.2M
The incorporation of human milk oligosaccharides in brain glycoconjugatesR01GM049077 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI LEBRILLA, CARLITO B · 1999 to 2024
$6.3M
Activation of probiotic bifidobacteria by milk glyansR01AT008759 · NCCIH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GERMAN, BRUCE, LEBRILLA, CARLITO B · 2014 to 2018
$4.2M
Necrotizing Enterocolitis: Prevention and PredictionR01HD059127 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEBRILLA, CARLITO B, MILLS, DAVID ANDREW · 2008 to 2012
$3.1M
Mechanism of Activation of Probiotic Bifidobacteria by Prebiotic Milk GlycansR01AT007079 · NCCIH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GERMAN, BRUCE, LEBRILLA, CARLITO B · 2012 to 2016
$2.2M
Structures, Functions, & Genetic Diversity of Oligosaccharides in MilkR01HD061923 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEBRILLA, CARLITO B · 2009 to 2013
$1.6M
NCATS NIH HHS UL1 TR000002NCCIH NIH HHS R01 AT007079NCCIH NIH HHS R01 AT008759NICHD NIH HHS R01 HD059127NICHD NIH HHS R01HD059127NICHD NIH HHS R01 HD061923NICHD NIH HHS R01HD061923NIGMS NIH HHS R01 GM049077
6 · The paper itself

Abstract

backgroundHuman milk oligosaccharides (HMOs) shape the intestinal microbiota in term infants. In premature infants, alterations in the intestinal microbiota (dysbiosis) are associated with risk of necrotizing enterocolitis (NEC) and sepsis, and the influence of HMOs on the microbiota is unclear.

methodsMilk, urine, and stool specimens from 14 mother-premature infant dyads were investigated by mass spectrometry for HMO composition. The stools were analyzed by next-generation sequencing to complement a previous analysis.

resultsPercentages of fucosylated and sialylated HMOs were highly variable between individuals but similar in urine, feces, and milk within dyads. Differences in urine and fecal HMO composition suggest variability in absorption. Secretor status of the mother correlated with the urine and fecal content of specific HMO structures. Trends toward higher levels of Proteobacteria and lower levels of Firmicutes were noted in premature infants of nonsecretor mothers. Specific HMO structures in the milk, urine, and feces were associated with alterations in fecal Proteobacteria and Firmicutes.

conclusionHMOs may influence the intestinal microbiota in premature infants. Specific HMOs, for example those associated with secretor mothers, may have a protective effect by decreasing pathogens associated with sepsis and NEC, while other HMOs may increase dysbiosis in this population.

Indexed as

Breast FeedingGastrointestinal MicrobiomeIntestinal AbsorptionDNA, BacterialDysbiosisFecesGestational AgeHigh-Throughput Nucleotide SequencingHumansInfant, NewbornInfant, PrematureIntestinal MucosaIntestinesMass SpectrometryMilk, HumanOligosaccharidesDNA, BacterialOligosaccharidesPrebiotics

Identifiers

PMID26322410
PMCPMC4689671
OpenAlexW1427125429

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.