ArticlePediatric research2015
Fully automated predictive intelligent control of oxygenation (PRICO) in resuscitation and ventilation of preterm lambs.
Article in Pediatric research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06117683 (Non-inferiority Comparative Trial Between Sotair® Device Attached to Manual Resuscitator Versus Mechanical Ventilation in Patients Undergoing Non-emergent Surgery With General Anesthesia), which is not on this map. Cited by 11 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Non-inferiority Comparative Trial Between Sotair® Device Attached to Manual Resuscitator Versus Mechanical Ventilation in Patients Undergoing Non-emergent Surgery With General Anesthesia
Who cites it
11 citing papers in PubMed, 36 citations in OpenAlex.
- Performance and safety of the PRICO closed-loop oxygen saturation targeting system in neonates: pragmatic multicentre cross-over study (TarOx Study).BMJ paediatrics open · 2024Trial
- Closed-Loop Automated Oxygen Control in Preterm Infants Receiving Non-Invasive Respiratory Support.Children (Basel, Switzerland) · 2025Review
- [Application of intelligent oxygen management system in neonatal intensive care units: a scoping review].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Article
- Addressing the Humans in the Delivery Room-Optimising Neonatal Monitoring and Decision-Making in Transition.Children (Basel, Switzerland) · 2025Review
- Gold Mesoporous Silica-Coated Nanoparticles for Quantifying and Qualifying Mesenchymal Stem Cell Distribution; a Proof-of-Concept Study in Large Animals.ACS applied bio materials · 2025Article
- Enhancing the estimation of PaCOBiomedical engineering online · 2024Article
- Stochastic integrated model-based protocol for volume-controlled ventilation setting.Biomedical engineering online · 2022Article
- Automated Oxygen Delivery in Neonatal Intensive Care.Frontiers in pediatrics · 2022Review
- Stimulating and maintaining spontaneous breathing during transition of preterm infants.Pediatric research · 2021Review
- Haemodynamic Instability and Brain Injury in Neonates Exposed to Hypoxia⁻Ischaemia.Brain sciences · 2019Review
- Can the preterm lung recover from perinatal stress?Molecular and cellular pediatrics · 2016Review
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHyperoxia and hypoxia influence morbidity and mortality of preterm infants. Automated closed-loop control of the fraction of inspired oxygen (FiO(2)) has been shown to facilitate oxygen supplementation in the neonatal intensive care unit (NICU), but has not yet been tested during preterm resuscitation. We hypothesized that fully automated FiO(2) control based on predefined oxygen saturation (SpO(2)) targets was applicable in both preterm resuscitation and ventilation.
methodsTwenty-two preterm lambs were operatively delivered and intubated in a modified EXIT procedure. They were randomized to receive standardized resuscitation with either automated or manual FiO(2) control, targeting SpO(2) according to the Dawson curve in the first 10 min and SpO(2) 90-95% hereafter. Automated FiO(2) control also was applied during surfactant replacement therapy and subsequent ventilation.
resultsTime within target range did not differ significantly between manual and automated FiO(2) control during resuscitation, however automated FiO(2) control significantly avoided hyperoxia. Automated FiO(2) control was feasible during surfactant replacement and kept SpO(2) within target range significantly better than manual control during subsequent ventilation.
conclusionIn our model, fully automated FiO(2) control was feasible in rapidly changing physiologic conditions during postnatal resuscitation and prevented hyperoxia. We conclude that closed loop FiO(2) control is a promising tool for the delivery room.
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