Evidence map›Paper›PMID 26322389›Full record

ArticleAmerican journal on intellectual and developmental disabilities2015

Do Children With Fragile X Syndrome Show Declines or Plateaus in Adaptive Behavior?

Laura J Hahn, Nancy C Brady, Steven F Warren, Kandace K Fleming

Abstract read
In one paragraph

Article in American journal on intellectual and developmental disabilities, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Retrospective Reports of Skill Attainment and Loss in Phelan-McDermid Syndrome.American journal on intellectual and developmental disabilities · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Daily Living Skills in Adolescent and Young Adult Males With Fragile X Syndrome.American journal on intellectual and developmental disabilities · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Toilet Training in Fragile X Syndrome.Journal of developmental and behavioral pediatrics : JDBP · 2019
    Article
  14. Article
  15. Adaptive behavior in infants and toddlers with Down syndrome and fragile X syndrome.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2018
    Article
  16. Article
  17. Article
  18. Growth of Expressive Syntax in Children With Fragile X Syndrome.Journal of speech, language, and hearing research : JSLHR · 2017
    Article
  19. Joint Attention and Early Social Developmental Cascades in Neurogenetic Disorders.International review of research in developmental disabilities · 2016
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Laura J Hahn
Nancy C Brady
Steven F Warren
Kandace K Fleming

Funding

UNC MRDD Research CenterP30HD003110 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BELGER, AYSENIL · 1985 to 2012
$28.7M
Research Design and Analysis Core (RDAC)P30HD002528 · NICHD · UNIVERSITY OF KANSAS LAWRENCE · PI FOWLER, STEPHEN CLETIUS · 1985 to 2015
$22.1M
Postdoctoral Training in Translational IDD ResearchT32HD057844 · NICHD · UNIVERSITY OF KANSAS LAWRENCE · PI SAUNDERS, KATHRYN J · 2009 to 2013
$801k
NICHD NIH HHS P30 HD002528NICHD NIH HHS P30 HD003110NICHD NIH HHS T32 HD057844
6 · The paper itself

Abstract

This study explores if children with fragile X syndrome (FXS) show advances, declines, or plateaus in adaptive behavior over time and the relationship of nonverbal cognitive abilities and autistic behavior on these trajectories. Parents of 55 children with FXS completed the Vineland Adaptive Behavior Scales ( Sparrow, Balla, & Cicchetti, 1984 ; Sparrow, Cicchetti, & Balla, 2005 ) between 3 and 6 times from 2 to 10 years of age. Using raw scores, results indicate that about half of the sample showed advances in adaptive behavior, whereas the other half showed declines, indicating a regression in skills. Children who were more cognitively advanced and had less autistic behaviors had higher trajectories. Understanding the developmental course of adaptive behavior in FXS has implications for educational planning and intervention, especially for those children showing declines.

Indexed as

Disease ProgressionAdaptation, PsychologicalChildChild DevelopmentChild, PreschoolFemaleFragile X SyndromeHumansMaleadaptive behaviordevelopmental trajectoryfragile X syndrome

Identifiers

PMID26322389
PMCPMC4557623

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.