ArticleeNeuro
Acetylcholine Acts through Nicotinic Receptors to Enhance the Firing Rate of a Subset of Hypocretin Neurons in the Mouse Hypothalamus through Distinct Presynaptic and Postsynaptic Mechanisms
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- New medications development for smoking cessation.Addiction neuroscience · 2023Article
- Cholinergic depolarization recruits a persistent CaJournal of neurophysiology · 2023Article
- Activity of a direct VTA to ventral pallidum GABA pathway encodes unconditioned reward value and sustains motivation for reward.Science advances · 2022Article
- Sex- and Stress-Dependent Effects on Dendritic Morphology and Spine Densities in Putative Orexin Neurons.Neuroscience · 2019Article
- Effects of Intranasal Orexin-A (Hypocretin-1) Administration on Neuronal Activation, Neurochemistry, and Attention in Aged Rats.Frontiers in aging neuroscience · 2019Article
- Regulation of Lateral Hypothalamic Orexin Activity by Local GABAergic Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Nicotinic Cholinergic System in the Hypothalamus Modulates the Activity of the Hypothalamic Neuropeptides During the Stress Response.Current neuropharmacology · 2018Review
- Whole-cell Currents Induced by Puff Application of GABA in Brain Slices.Journal of visualized experiments : JoVE · 2017Article
- Optogenetic approach for targeted activation of global calcium transients in differentiated C2C12 myotubes.Scientific reports · 2017Article
- Enduring effects of perinatal nicotine exposure on murine sleep in adulthood.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Orexin/Hypocretin System: Role in Food and Drug Overconsumption.International review of neurobiology · 2017Review
- The Obesity-Impulsivity Axis: Potential Metabolic Interventions in Chronic Psychiatric Patients.Frontiers in psychiatry · 2017Review
- Hypocretinergic and cholinergic contributions to sleep-wake disturbances in a mouse model of traumatic brain injury.Neurobiology of sleep and circadian rhythms · 2017Article
- Nicotinic receptor activation contrasts pathophysiological bursting and neurodegeneration evoked by glutamate uptake block on rat hypoglossal motoneurons.The Journal of physiology · 2016Article
- Nicotinic receptor blockade decreases fos immunoreactivity within orexin/hypocretin-expressing neurons of nicotine-exposed rats.Behavioural brain research · 2016Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Hypocretin/orexin neurons regulate many behavioral functions, including addiction. Nicotine acts through nicotinic acetylcholine receptors (nAChRs) to alter firing rate of neurons throughout the brain, leading to addiction-related behaviors. While nAChRs are expressed in the hypothalamus and cholinergic fibers project to this structure, it is unclear how acetylcholine modulates the activity of hypocretin neurons. In this study, we stimulated hypocretin neurons in mouse brain slices with ACh in the presence of atropine to dissect presynaptic and postsynaptic modulation of these neurons through nAChRs. Approximately one-third of tested hypocretin neurons responded to pressure application of ACh (1 mM) with an increase in firing frequency. Stimulation of postsynaptic nAChRs with ACh or nicotine resulted in a highly variable inward current in approximately one-third of hypocretin neurons. In contrast, ACh or nicotine (1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.