ArticleAdvanced biomedical research2015
Neuroprotective effects of Rosa damascena extract on learning and memory in a rat model of amyloid-β-induced Alzheimer's disease.
Article in Advanced biomedical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
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- Celery flavonoid-rich extract significantly reduces cucumber powdery mildew severity and enhances plant defense responses.Scientific reports · 2025Article
- Review
- Exploring Medicinal Herbs' Therapeutic Potential and Molecular Docking Analysis for Compounds as Potential Inhibitors of Human Acetylcholinesterase in Alzheimer's Disease Treatment.Medicina (Kaunas, Lithuania) · 2023Article
- Neural Stem Cells Secretome Increased Neurogenesis and Behavioral Performance and the Activation of Wnt/β-Catenin Signaling Pathway in Mouse Model of Alzheimer's Disease.Neuromolecular medicine · 2022Article
- The effect of Zingiber Officinale Extract on Preventing Demyelination of Corpus Callosum in a Rat Model of Multiple SclerosisIranian biomedical journal · 2022Article
- Effects of the hydroalcoholic extract of Rosa damascena on hippocampal long-term potentiation in rats fed high-fat diet.The journal of physiological sciences : JPS · 2021Article
- Effects of Hypericum scabrum extract on dentate gyrus synaptic plasticity in high fat diet-fed rats.The journal of physiological sciences : JPS · 2020Article
- Amyloidogenic Peptides in Human Neuro-Degenerative Diseases and in Microorganisms: A Sorrow Shared Is a Sorrow Halved?Molecules (Basel, Switzerland) · 2020Review
- The Interplay Between Beta-Amyloid 1-42 (AβFrontiers in molecular neuroscience · 2020Article
- The Effects of Yuan-Zhi Decoction and Its Active Ingredients in BothEvidence-based complementary and alternative medicine : eCAM · 2020Article
- Diet therapy for the treatment of Alzheimer's disease in view of traditional Persian medicine: A review.Iranian journal of basic medical sciences · 2019Review
- Exercise as a Positive Modulator of Brain Function.Molecular neurobiology · 2018Review
- Unraveling the novel effects of aroma from small molecules in preventing hen egg white lysozyme amyloid fibril formation.PloS one · 2018Article
- Effects of the hydroalcoholic extract of Rosa damascena on learning and memory in male rats consuming a high-fat diet.Pharmaceutical biology · 2017Article
- Peripheral and central administration of T3 improved the histological changes, memory and the dentate gyrus electrophysiological activity in an animal model of Alzheimer's disease.Metabolic brain disease · 2017Article
- Therapeutic Applications of Rose Hips from Different Rosa Species.International journal of molecular sciences · 2017Review
- Comparison of the glycopattern alterations of mitochondrial proteins in cerebral cortex between rat Alzheimer's disease and the cerebral ischemia model.Scientific reports · 2017Article
- A review on the management of migraine in the Avicenna's Canon of Medicine.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2016Review
- Topical application of medicinal plant oils in pediatric-related disorders: A comparative review article based on traditional Persian medicine.Avicenna journal of phytomedicineReview
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7 authors.
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Abstract
backgroundAlzheimer's disease (AD) is an age-related progressive neurodegenerative disease, which is characterized clinically by serious impairment in memory and cognition. Current medications only slow down the dementia progression and the present treatment one-drug one-target paradigm for anti-AD treatment appears to be clinically unsuccessful. Therefore, alternative therapeutic strategies are urgently needed. With respect to multifunctional and multitargeted characteristics of Rosa damascena via its effective flavonoids, we investigated the effects of R. damascena extract on behavioral functions in a rat model of amyloid-β (A-β)-induced Alzheimer's disease. MATERIALS AND
methodsAfter preparation of the methanolic extract of the R. damascena, HPLC analysis and toxicity studies, median lethal dose (LD50) and dose levels were determined. For evaluation of baseline training behavioral performance, Morris water maze and passive avoidance tests were used. A-β was injected bilaterally into CA1 area of the hippocampus. Twenty-one days after injection of A-β, the first probe trial of the behavioral tests were used to confirm learning and memory impairment. To examine the potential effects of the extract on behavioral tasks, the second probe trials were performed after one month administration of R. damasena extract.
resultsResults showed that the R. damascena extract significantly improved the spatial and long-term memories in the extract- treated groups in a dose-dependent manner, as in the middle and high doses it had significant effect.
conclusionAccording to these results, we concluded that R. damascena can reverse behavioral deficits caused by A-β, and may provide a new potential option for prevention and treatment of the cognitive dysfunction in Alzheimer's disease.
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