ArticleAddiction & health
Post-operative Analgesia in Opioid Dependent Patients: Comparison of Intravenous Morphine and Sublingual Buprenorphine.
Article in Addiction & health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Impact of preoperative opioid exposure on cost of care and workplace productivity loss after elective surgery.Regional anesthesia and pain medicine · 2026Article
- Strategies for Treating Acute Pain in Patients with Opioid Dependence, Opioid Use Disorder, or Long-Term Opioid Therapy: A Scoping Review.International journal of general medicine · 2026Review
- The Efficacy of Buprenorphine in Preoperative and Postoperative Patients: A Literature Review.Cureus · 2024Review
- Substance abuse screening prior to bariatric surgery: an MBSAQIP cohort study evaluating frequency and factors associated with screening.Surgical endoscopy · 2023Article
- The Effect of Nicotine Patch on Reducing Nausea, Vomiting, and Pain Following Laparoscopic Cholecystectomy: A Randomized Clinical Trial.Addiction & health · 2023Article
- Effectiveness of Sublingual Buprenorphine and Fentanyl Pump in Controlling Pain After Open Cholecystectomy.Anesthesiology and pain medicine · 2021Article
- Targeting practitioners: A review of guidelines, training, and policy in pain management.Drug and alcohol dependence · 2017Review
- SCAMPs for Multimodal Post-Operative Analgesia: A Concept to Standardize and Individualize Care.Current pain and headache reports · 2017Review
- Efficacy and safety of sublingual buprenorphine in managing acute postoperative pain - A systematic review.Journal of anaesthesiology, clinical pharmacologyReview
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute and chronic pain is prevalent in patients with opioid dependence. Lack of knowledge concerning the complex relationship between pain, opioid use, and withdrawal syndrome can account for the barriers encountered for pain management. This study was designed to evaluate the efficacy of sublingual (SL) buprenorphine for post-operative analgesia, compared with intravenous (IV) morphine.
methodsA total of 68 patients, aged 20-60 years were randomly selected from whom had been underwent laparotomy due to acute abdomen in a University Teaching Hospital in Arak, Iran, and were also opioid (opium or heroin) abuser according to their history. After end of the surgery and patients' arousal, the patients were evaluated for abdominal pain and withdrawal syndrome by visual analog scale (VAS) and clinical opioid withdrawal score (COWS), respectively 1, 6, and 24 h after the surgery. They received either morphine 5 mg IV or buprenorphine 2 mg SL, 1 h after end of the surgery, and then every 6 h for 24 h.
findingsVAS was 4.47 ± 0.73 and 2.67 ± 0.53 at h 6 and 24 in buprenorphine group, respectively. The corresponding score was 5.88 ± 0.69 and 4.59 ± 0.74 in morphine group. At the same time, patients in buprenorphine experienced less severe withdrawal syndrome.
conclusionThe present study confirmed the efficacy of SL buprenorphine as a non-invasive, but effective method for management of post-operative pain in opioid dependent patients. Result of this study showed that physicians can rely on SL buprenorphine for post-operative analgesia.
Indexed as
Identifiers
26322212PMC4530195What OpenQuestion holds
Registered trials
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