ArticleGut pathogens2015
High dietary zinc supplementation increases the occurrence of tetracycline and sulfonamide resistance genes in the intestine of weaned pigs.
Article in Gut pathogens, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 108 citations in OpenAlex.
- Age- and diet-driven assembly of the gut antibiotic resistome in humans and food-producing animals.Gut microbes · 2026Review
- Robust detection in faeces andVeterinary and animal science · 2026Article
- Probiotics and enzymes in weaned piglets' diets can lower belly nosing frequency and improve performance and nitrogen balance.Tropical animal health and production · 2026Article
- Severity-dependent alterations in oral microbiota and antibiotic resistance in children with dental fluorosis.Journal of oral microbiology · 2026Article
- Producer perceptions on the impacts of the withdrawal of zinc oxide on the health and welfare of weaned pigs.Frontiers in veterinary science · 2026Article
- Effect ofAnimals : an open access journal from MDPI · 2025Article
- Zinc and animal health: an in-depth exploration of its role in physiological functions and regulatory molecular mechanisms.Journal of animal science and biotechnology · 2025Review
- Cross-sectional survey of risk factors for edema disease Escherichia coli (EDEC) on commercial pig farms in Germany.BMC veterinary research · 2025Article
- Benzoic acid-the cornerstone of any swine nutrition program.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Review
- Antimicrobial resistance in Escherichia coli from Swedish piglets with diarrhoea and associations with potential risk factors.Acta veterinaria Scandinavica · 2025Article
- Effects of monoglyceride blend on performance and intestinal health status of piglets fed diets without growth promoters.Scientific reports · 2025Article
- Impact of zinc oxide on gut health, immunity, and growth in weaned piglets: exploring potential modes of action.Frontiers in veterinary science · 2025Article
- Safety and immunomodulatory efficacy of heat-killedFrontiers in veterinary science · 2025Article
- The Mechanism of Zinc Oxide in Alleviating Diarrhea in Piglets after Weaning: A Review from the Perspective of Intestinal Barrier Function.International journal of molecular sciences · 2024Review
- Extended-spectrum β-lactamase-producingVeterinary world · 2024Review
- Gut microbiome and resistome characterization of pigs treated with commonly used post-weaning diarrhea treatments.Animal microbiome · 2024Article
- Impact of zinc supplementation on phenotypic antimicrobial resistance of fecal commensal bacteria from pre-weaned dairy calves.Scientific reports · 2024Article
- Exploring zinc deficiency using serum Zn levels: consequences and potential solutions in suckling pigs.Journal of animal science · 2024Article
- Whole genome sequence analysis reveals high genomic diversity and potential host-driven adaptations among multidrug-resistantFrontiers in microbiology · 2024Article
- Probiotics and Postbiotics as an Alternative to Antibiotics: An Emphasis on Pigs.Pathogens (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDietary zinc oxide is used in pig nutrition to combat post weaning diarrhoea. Recent data suggests that high doses (2.5 g/kg feed) increase the bacterial antibiotic resistance development in weaned pigs. Therefore, the aim of this study was to investigate the development of enterobacterial antibiotic resistance genes in the intestinal tract of weaned pigs.
findingsWeaned pigs were fed diets for 4 weeks containing 57 (low), 164 (intermediate) or 2425 (high) mg kg(-1) analytical grade ZnO. DNA extracts from stomach, mid-jejunum, terminal ileum and colon ascendens were amplified by qPCR assays to quantify copy numbers for the tetracycline (tetA) and sulfonamide (sul1) resistance genes in Gram-negative bacteria. Overall, the combined data (n = 336) showed that copy numbers for tetracycline and sulfonamide resistance genes were significantly increased in the high zinc treatment compared to the low (tetA: p value < 10(-6); sul1: p value = 1 × 10(-5)) or intermediate (tetA: P < 1.6 × 10(-4); sul1: P = 3.2 × 10(-4)) zinc treatment. Regarding the time dependent development, no treatment effects were seen 1 week after weaning, but significant differences between high and low/intermediate zinc treatments evolved 2 weeks after weaning. The increased number of tetA and sul1 copies was not confined to the hind gut, but was already present in stomach contents.
conclusionsThe results of this study suggest that the use of high doses of dietary zinc beyond 2 weeks after weaning should be avoided in pigs due to the possible increase of antibiotic resistance in Gram-negative bacteria.
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