ArticleFrontiers in microbiology2015
Assessing the antibiotic susceptibility of freshwater Cyanobacteria spp.
Article in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Targeted genome editing of the non-model cyanobacterium Cyanothece PCC 7425 via CRISPR/Cas12a.Applied microbiology and biotechnology · 2026Article
- Functional characterization of macrolide esterase from cyanobacteria and their potential dissemination risk.npj antimicrobials and resistance · 2026Article
- Prediction of Antibiotic Resistance Genes in Cyanobacterial Strains by Whole Genome Sequencing.Microorganisms · 2025Article
- A toolbox to engineer the highly productive cyanobacterium Synechococcus sp. PCC 11901.Plant physiology · 2024Article
- Assessing the Ecotoxicity of Eight Widely Used Antibiotics on River Microbial Communities.International journal of molecular sciences · 2023Article
- The β-Lactamase Activity at the Community Level Confers β-Lactam Resistance to Bloom-Forming Microcystis aeruginosa Cells.Journal of microbiology (Seoul, Korea) · 2023Article
- Responses of the Soil Bacterial Community, Resistome, and Mobilome to a Decade of Annual Exposure to Macrolide Antibiotics.Applied and environmental microbiology · 2022Article
- Antibiotic-Induced Changes in Pigment Accumulation, Photosystem II, and Membrane Permeability in a Model Cyanobacterium.Frontiers in microbiology · 2022Article
- The link between pharmaceuticals and cyanobacteria: a review regarding ecotoxicological, ecological, and sanitary aspects.Environmental science and pollution research international · 2021Review
- Amino Acid Analog Induces Stress Response in MarineApplied and environmental microbiology · 2021Article
- Cyanobacterial blooms contribute to the diversity of antibiotic-resistance genes in aquatic ecosystems.Communications biology · 2020Article
- Characteristics of toxin production and release in Microcystis aeruginosa exposed to three tetracycline antibiotics.Environmental science and pollution research international · 2020Article
- Effect of PHRs and PCPs on Microalgal Growth, Metabolism and Microalgae-Based Bioremediation Processes: A Review.International journal of molecular sciences · 2019Review
- Metagenomics Reveals the Impact of Wastewater Treatment Plants on the Dispersal of Microorganisms and Genes in Aquatic Sediments.Applied and environmental microbiology · 2018Article
- Article
- The Combined Use ofFrontiers in pharmacology · 2017Article
- Structural Elucidation and Molecular Docking of a Novel Antibiotic Compound from CyanobacteriumFrontiers in microbiology · 2016Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Freshwater is a vehicle for the emergence and dissemination of antibiotic resistance. Cyanobacteria are ubiquitous in freshwater, where they are exposed to antibiotics and resistant organisms, but their role on water resistome was never evaluated. Data concerning the effects of antibiotics on cyanobacteria, obtained by distinct methodologies, is often contradictory. This emphasizes the importance of developing procedures to understand the trends of antibiotic susceptibility in cyanobacteria. In this study we aimed to evaluate the susceptibility of four cyanobacterial isolates from different genera (Microcystis aeruginosa, Aphanizomenon gracile, Chrisosporum bergii, Planktothix agradhii), and among them nine isolates from the same specie (M. aeruginosa) to distinct antibiotics (amoxicillin, ceftazidime, ceftriaxone, kanamycine, gentamicine, tetracycline, trimethoprim, nalidixic acid, norfloxacin). We used a method adapted from the bacteria standard broth microdilution. Cyanobacteria were exposed to serial dilution of each antibiotic (0.0015-1.6 mg/L) in Z8 medium (20 ± 1°C; 14/10 h L/D cycle; light intensity 16 ± 4 μEm(-2)s(-1)). Cell growth was followed overtime (OD450nm /microscopic examination) and the minimum inhibitory concentrations (MICs) were calculated for each antibiotic/isolate. We found that β-lactams exhibited the lower MICs, aminoglycosides, tetracycline and norfloxacine presented intermediate MICs; none of the isolates were susceptible to trimethoprim and nalidixic acid. The reduced susceptibility of all tested cyanobacteria to some antibiotics suggests that they might be naturally non-susceptible to these compounds, or that they might became non-susceptible due to antibiotic contamination pressure, or to the transfer of genes from resistant bacteria present in the environment.
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