ArticleFrontiers in microbiology2015
Role of Cln1 during melanization of Cryptococcus neoformans.
Article in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Immune Modulation and Evasion byACS omega · 2026Review
- Role of the Anaphase-Promoting Complex Activator Cdh1 in the Virulence ofJournal of fungi (Basel, Switzerland) · 2024Article
- Antifungal activity of the repurposed drug disulfiram againstFrontiers in pharmacology · 2023Article
- The Cryptococcus gattii species complex: Unique pathogenic yeasts with understudied virulence mechanisms.PLoS neglected tropical diseases · 2022Review
- Phenotypic Diversity ofMicroorganisms · 2022Article
- A cyclin protein governs the infectious and sexual life cycles of Cryptococcus neoformans.Science China. Life sciences · 2021Article
- Extracellular Vesicles in the Fungi Kingdom.International journal of molecular sciences · 2021Review
- Effect ofCurrent medical mycology · 2021Article
- Article
- The Cryptococcus neoformans Titan cell is an inducible and regulated morphotype underlying pathogenesis.PLoS pathogens · 2018Article
- Polyketide synthases of Diaporthe helianthi and involvement of DhPKS1 in virulence on sunflower.BMC genomics · 2018Article
- N-acetylglucosamine affects Cryptococcus neoformans cell-wall composition and melanin architecture.Microbiology (Reading, England) · 2017Article
- Connecting virulence pathways to cell-cycle progression in the fungal pathogen Cryptococcus neoformans.Current genetics · 2017Review
- Investigating Conservation of the Cell-Cycle-Regulated Transcriptional Program in the Fungal Pathogen, Cryptococcus neoformans.PLoS genetics · 2016Article
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
Cryptococcus neoformans is an opportunistic fungal pathogen that has several well-described virulence determinants. A polysaccharide capsule and the ability to produce melanin are among the most important. Melanization occurs both in vitro, in the presence of catecholamine and indole compounds, and in vivo during the infection. Despite the importance of melanin production for cryptococcal virulence, the component and mechanisms involved in its synthesis have not been fully elucidated. In this work, we describe the role of a G1/S cyclin (Cln1) in the melanization process. Cln1 has evolved specifically with proteins present only in other basidiomycetes. We found that Cln1 is required for the cell wall stability and production of melanin in C. neoformans. Absence of melanization correlated with a defect in the expression of the LAC1 gene. The relation between cell cycle elements and melanization was confirmed by the effect of drugs that cause cell cycle arrest at a specific phase, such as rapamycin. The cln1 mutant was consistently more susceptible to oxidative damage in a medium that induces melanization. Our results strongly suggest a novel and hitherto unrecognized role for C. neoformans Cln1 in the expression of virulence traits.
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