Evidence map›Paper›PMID 26322020›Full record

ReviewFrontiers in endocrinology2015

RXFP1 is Targeted by Complement C1q Tumor Necrosis Factor-Related Factor 8 in Brain Cancer.

Thatchawan Thanasupawat, Aleksandra Glogowska, Maxwell Burg, G William Wong, Cuong Hoang-Vu, Sabine Hombach-Klonisch, Thomas Klonisch

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Thatchawan ThanasupawatDepartment of Human Anatomy and Cell Science, Faculty of Health Sciences, College of Medicine, University of Manitoba , Winnipeg, MB , Canada.
Aleksandra GlogowskaDepartment of Human Anatomy and Cell Science, Faculty of Health Sciences, College of Medicine, University of Manitoba , Winnipeg, MB , Canada.
Maxwell BurgDepartment of Human Anatomy and Cell Science, Faculty of Health Sciences, College of Medicine, University of Manitoba , Winnipeg, MB , Canada.
G William WongDepartment of Physiology, Center for Metabolism and Obesity Research, Johns Hopkins University School of Medicine , Baltimore, MD , USA.
Cuong Hoang-VuClinics of General, Visceral and Vascular Surgery, Martin Luther University , Halle/Salle , Germany.
Sabine Hombach-KlonischDepartment of Human Anatomy and Cell Science, Faculty of Health Sciences, College of Medicine, University of Manitoba , Winnipeg, MB , Canada ; Department of Obstetrics, Gynecology and Reproductive Medicine, Faculty of Health Sciences, College of Medicine, University of Manitoba , Winnipeg, MB , Canada.
Thomas KlonischDepartment of Human Anatomy and Cell Science, Faculty of Health Sciences, College of Medicine, University of Manitoba , Winnipeg, MB , Canada ; Department of Surgery, Faculty of Health Sciences, College of Medicine, University of Manitoba , Winnipeg, MB , Canada ; Department of Medical Microbiology and Infectious Diseases, Faculty of Health Sciences, College of Medicine, University of Manitoba , Winnipeg, MB , Canada.
University of Manitoba · CAJohns Hopkins Medicine · USMartin Luther University Halle-Wittenberg · DE

Funding

CTRP and Metabolic ControlR01DK084171 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI Guang William Wong · 2010 to 2026
$8.0M
NIDDK NIH HHS R01 DK084171
6 · The paper itself

Abstract

The relaxin-like RXFP1 ligand-receptor system has important functions in tumor growth and tissue invasion. Recently, we have identified the secreted protein, CTRP8, a member of the C1q/tumor necrosis factor-related protein (CTRP) family, as a novel ligand of the relaxin receptor, RXFP1, with functions in brain cancer. Here, we review the role of CTRP members in cancers cells with particular emphasis on CTRP8 in glioblastoma.

Indexed as

brain tumorC1q/TNF-related proteinscancerCTRP8RXFP1

Identifiers

PMID26322020
PMCPMC4534857
OpenAlexW2159025060

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.