Evidence map›Paper›PMID 26321947›Full record

ArticleFrontiers in aging neuroscience2015

Force Variability during Dexterous Manipulation in Individuals with Mild to Moderate Parkinson's Disease.

Na-Hyeon Ko, Christopher M Laine, Beth E Fisher, Francisco J Valero-Cuevas

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Na-Hyeon KoBrain-Body Dynamics Laboratory, Department of Biomechanical Engineering, Division of Biokinesiology and Physical Therapy, University of Southern California Los Angeles , Los Angeles, CA , USA ; Neuroplasticity and Neuroimaging Laboratory, Division of Biokinesiology and Physical Therapy, University of Southern California Los Angeles , Los Angeles, CA , USA.
Christopher M LaineBrain-Body Dynamics Laboratory, Department of Biomechanical Engineering, Division of Biokinesiology and Physical Therapy, University of Southern California Los Angeles , Los Angeles, CA , USA.
Beth E FisherNeuroplasticity and Neuroimaging Laboratory, Division of Biokinesiology and Physical Therapy, University of Southern California Los Angeles , Los Angeles, CA , USA.
Francisco J Valero-CuevasBrain-Body Dynamics Laboratory, Department of Biomechanical Engineering, Division of Biokinesiology and Physical Therapy, University of Southern California Los Angeles , Los Angeles, CA , USA.
University of Southern California · US

Funding

Structure &function of the fingers tendinous apparatusR01AR052345 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VALERO-CUEVAS, FRANCISCO J · 2005 to 2017
$3.7M
Control of finger movement and force for precision pinchR01AR050520 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VALERO-CUEVAS, FRANCISCO J · 2004 to 2014
$2.9M
NIAMS NIH HHS R01 AR050520NIAMS NIH HHS R01 AR052345
6 · The paper itself

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disease affecting about 1-2% of the population over the age of 65. Individuals with PD experience gradual deterioration of dexterous manipulation for activities of daily living; however, current clinical evaluations are mostly subjective and do not quantify changes in dynamic control of fingertip force that is critical for manual dexterity. Thus, there is a need to develop clinical measures to quantify those changes with aging and disease progression. We investigated the dynamic control of fingertip forces in both hands of 20 individuals with PD (69.0 ± 7.4 years) using the Strength-Dexterity test. The test requires low forces (<3 N) to compress a compliant and slender spring prone to buckling. A maximal level of sustained compression is informative of the greatest instability the person can control, and thus is indicative of the integrity of the neuromuscular system for dexterous manipulation. Miniature sensors recorded fingertip force (F) during maximal sustained compressions. The force variability during sustained compression was quantified in two frequency bands: low (<4 Hz, F_LF) and high (4-12 Hz, F_HF). F_LF characterizes variability in voluntary fluctuations, while F_HF characterizes variability in involuntary fluctuations including tremor. The more-affected hand exhibited significantly lower F and lower F_LF than those in the less-affected hand. The more-affected hand showed significant negative correlations between F_LF and the Unified Parkinson's Disease Rating Scale motor scores for both total and hand-only, suggesting that greater force variability in the voluntary range was associated with less clinical motor impairment. We conclude the nature of force variability in the voluntary range during this dynamic and dexterous task may be a biomarker of greater motor capability/flexibility/adaptability in PD. This approach may provide a more quantitative clinical assessment of changes of sensorimotor control in individuals with PD.

Indexed as

clinical evaluationsdexteritydynamic force controlfingersforce variabilityParkinson’s diseasesensorimotor control

Identifiers

PMID26321947
PMCPMC4530309
OpenAlexW1562465373

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.