ArticleContemporary clinical dentistry
An appraisal of innovative meloxicam mucoadhesive films for periodontal postsurgical pain control: A double-blinded, randomized clinical trial of effectiveness.
Article in Contemporary clinical dentistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Pharmacological management of pain after periodontal surgery: a systematic review with meta-analysis.Clinical oral investigations · 2020Pooled it
- Evaluation of the effect of green tea extract on postoperative pain management following surgical removal of impacted mandibular third molar.Dental research journal · 2023Article
- Meloxicam in the management of post-operative pain: Narrative review.Journal of anaesthesiology, clinical pharmacologyReview
- Evaluation of a curcumin-containing mucoadhesive film for periodontal postsurgical pain control.Journal of Indian Society of PeriodontologyArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveTransmucosal analgesic delivery is a promising approach to periodontal postoperative pain management. The purpose of this clinical trial is to appraise the effectiveness of transmucosal drug delivery system with meloxicam films and to identify its minimum effective dosage via this route after periodontal flap surgery. MATERIALS AND
methodsThe analgesic mucoadhesive films were formulated using meloxicam and hydroxypropyl methyl cellulose polymer by solvent casting method. The sample size consisted of 60 chronic periodontitis patients who require periodontal flap surgery. The subjects were randomized using lottery method into four groups (Group A - 45 mg; B - 30 mg; C - 20 mg; D - 10 mg meloxicam per film). After periodontal flap surgery, the respective meloxicam mucoadhesive films were placed over the surgical site and were removed on 4(th) day of postsurgery. The primary outcome measure was postsurgical pain level and recorded at 1(st), 2(nd), 3(rd), 4(th), 5(th), 24(th), and 48(th) h using a 0-10 mm visual analog scale with markings from 0 = no pain to 10 = extreme pain.
resultsThe postoperative pain control observed in Groups A and B was found to be effective, and the patient comfort level was very satisfactory. Whereas in Group C, it was found to be high in the first 3 h postsurgically, after which adequate pain relief was seen. Group D exhibited inadequate pain relief. No adverse reactions were noted after applying the film in any of the groups.
conclusionTransmucosal delivery of meloxicam was found to be effective and safe in postsurgical pain control of periodontal flap surgery. The minimum effective dosage via this route for meloxicam was found to be with 30 mg mucoadhesive films.
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