ArticleCell reports2015
Transcription Profiling Demonstrates Epigenetic Control of Non-retroviral RNA Virus-Derived Elements in the Human Genome.
Article in Cell reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Article
- Genomic transfers help to decipher the ancient evolution of filoviruses and interactions with vertebrate hosts.PLoS pathogens · 2024Article
- Roles of Human Endogenous Retroviruses and Endogenous Virus-Like Elements in Cancer Development and Innate Immunity.Biomolecules · 2023Review
- Co-option of a non-retroviral endogenous viral element in planthoppers.Nature communications · 2023Article
- Antiviral Activity of an Endogenous Parvoviral Element.Viruses · 2023Article
- Article
- A Human Endogenous Bornavirus-Like Nucleoprotein Encodes a Mitochondrial Protein Associated with Cell Viability.Journal of virology · 2021Article
- Virus-like insertions with sequence signatures similar to those of endogenous nonretroviral RNA viruses in the human genome.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Effects of activation of the LINE-1 antisense promoter on the growth of cultured cells.Scientific reports · 2020Article
- Neo-virology: The raison d'etre of viruses.Virus research · 2019Article
- Molecular Properties and Evolutionary Origins of a Parvovirus-Derived Myosin Fusion Gene in Guinea Pigs.Journal of virology · 2019Article
- Genome-wide profiling of long noncoding RNA expression patterns and CeRNA analysis in mouse cortical neurons infected with different strains of borna disease virus.Genes & diseases · 2019Article
- Evolution of Immune Systems From Viruses and Transposable Elements.Frontiers in microbiology · 2019Review
- Systematic estimation of insertion dates of endogenous bornavirus-like elements in vesper bats.The Journal of veterinary medical science · 2018Article
- Divergent bornaviruses from Australian carpet pythons with neurological disease date the origin of extant Bornaviridae prior to the end-Cretaceous extinction.PLoS pathogens · 2018Article
- Putative endogenous filovirus VP35-like protein potentially functions as an IFN antagonist but not a polymerase cofactor.PloS one · 2017Article
- Potential Links between Hepadnavirus and Bornavirus Sequences in the Host Genome and Cancer.Frontiers in microbiology · 2017Review
- The bornavirus-derived human protein EBLN1 promotes efficient cell cycle transit, microtubule organisation and genome stability.Scientific reports · 2016Article
- Exaptation of Bornavirus-Like Nucleoprotein Elements in Afrotherians.PLoS pathogens · 2016Article
- An RNA-dependent RNA polymerase gene in bat genomes derived from an ancient negative-strand RNA virus.Scientific reports · 2016Article
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4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endogenous bornavirus-like nucleoprotein elements (EBLNs) are DNA sequences in vertebrate genomes formed by the retrotransposon-mediated integration of ancient bornavirus sequence. Thus, EBLNs evidence a mechanism of retrotransposon-mediated RNA-to-DNA information flow from environment to animals. Although EBLNs are non-transposable, they share some features with retrotransposons. Here, to test whether hosts control the expression of EBLNs similarly to retrotransposons, we profiled the transcription of all Homo sapiens EBLNs (hsEBLN-1 to hsEBLN-7). We could detect transcription of all hsEBLNs in at least one tissue. Among them, hsEBLN-1 is transcribed almost exclusively in the testis. In most tissues, expression from the hsEBLN-1 locus is silenced epigenetically. Finally, we showed the possibility that hsEBLN-1 integration at this locus affects the expression of a neighboring gene. Our results suggest that hosts regulate the expression of endogenous non-retroviral virus elements similarly to how they regulate the expression of retrotransposons, possibly contributing to new transcripts and regulatory complexity to the human genome.
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