ArticleCancer cell2015
Efficacy of Retinoids in IKZF1-Mutated BCR-ABL1 Acute Lymphoblastic Leukemia.
Open access · bronzeAbstract read
In one paragraph
Article in Cancer cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed, 1 pooled it
19.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
124 citing papers in PubMed, 1 synthesis or guideline pooled it, 215 citations in OpenAlex.
- Pooled it
- IL-6 receptor inhibition promotes expansion of cytolytic CD4+ T cells after cellular immunotherapy.Blood · 2026Article
- [Prognostic significance of IKZF1 alterations in acute B-lymphoblastic leukemia and the choice of transplantation strategy].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2026Review
- Systematic functional validation of IKAROS variants from patients and laboratory-generated mutations.Blood advances · 2026Article
- IKAROS Gene Regulatory Network Reveal ERG as a Vulnerability in B-cell Acute Lymphoblastic Leukemia.bioRxiv : the preprint server for biology · 2025Article
- EomesoderminImmunity · 2025Article
- B-cell lymphoblastic leukemia/lymphoma with mutatedHaematologica · 2025Article
- Review
- Exploring the impact of IKZF1 and its targeting microRNAs in the pathogenesis of acute lymphoblastic leukemia.Irish journal of medical science · 2025Article
- Heterogeneity of IKZF1 genomic alterations and risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia.Leukemia · 2025Article
- IKAROS levels are associated with antigen escape in CD19- and CD22-targeted therapies for B-cell malignancies.Nature communications · 2025Article
- Article
- CDCM: a correlation-dependent connectivity map approach to rapidly screen drugs during outbreaks of infectious diseases.Briefings in bioinformatics · 2024Article
- Genomic Determinants of Outcome in Acute Lymphoblastic Leukemia.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024Article
- Clonal evolution of the 3D chromatin landscape in patients with relapsed pediatric B-cell acute lymphoblastic leukemia.Nature communications · 2024Article
- A pre-B acute lymphoblastic leukemia cell line model reveals the mechanism of thalidomide therapy-related B-cell leukemogenesis.The Journal of biological chemistry · 2024Article
- Article
- Concepts in B cell acute lymphoblastic leukemia pathogenesis.Journal of leukocyte biology · 2024Review
- Emerging paradigms in cancer cell plasticity.BMB reports · 2024Review
- Article
64 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
45 authors at 6 institutions in 3 countries.
Michelle L ChurchmanDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Jonathan LowDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Chunxu QuDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Elisabeth M PaiettaDepartment of Medicine, Montefiore Medical Center, North Division, Bronx, NY 10466, USA.
Lawryn H KasperDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Yunchao ChangDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Debbie Payne-TurnerDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Mark J AlthoffDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Guangchun SongDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Shann-Ching ChenDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Jing MaDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Michael RuschDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Dan McGoldrickDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Michael EdmonsonDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Pankaj GuptaDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Yong-Dong WangDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
William CaufieldPreclinical Pharmacokinetics Shared Resource, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Burgess FreemanPreclinical Pharmacokinetics Shared Resource, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Lie LiDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
John C PanettaDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Sharyn BakerDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Yung-Li YangDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Kathryn G RobertsDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Kelly McCastlainDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Ilaria IacobucciDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Jennifer L PetersDepartment of Cellular Imaging Shared Resource, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Victoria E CentonzeDepartment of Cellular Imaging Shared Resource, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Faiyaz NottaPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1L7, Canada.
Stephanie M DobsonPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1L7, Canada.
Sasan ZandiPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1L7, Canada.
John E DickPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1L7, Canada.
Laura JankeDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Junmin PengDepartments of Structural Biology and Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; St. Jude Proteomics Facility, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Kiran KodaliSt. Jude Proteomics Facility, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Vishwajeeth PagalaSt. Jude Proteomics Facility, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Jaeki MinDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Anand MayasundariDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Richard T WilliamsPuma Biotechnology, Los Angeles, CA 90024, USA.
Cheryl L WillmanDepartment of Pathology, University of New Mexico Cancer Center, Albuquerque, NM 87131, USA.
Jacob RoweHematology, Shaare Zedek Medical Center, 9103102 Jerusalem, Israel.
Selina LugerHematology-Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.
Ross A DickinsThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
R Kiplin GuyDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Taosheng ChenDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Charles G MullighanDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: charles.mullighan@stjude.org.
St. Jude Children's Research Hospital · USUniversity Health Network · CAUniversity of Toronto · CAPuma Biotechnology (United States) · USUNM Comprehensive Cancer CenterWalter and Eliza Hall Institute of Medical Research · AU
Funding
Project-006U10CA180820 · NCI · ECOG-ACRIN MEDICAL RESEARCH FOUNDATION · PI Peter J ODwyer, MITCHELL D. SCHNALL · 2014 to 2026
$167.6MViral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9MECOG OPERATIONS OFFICE (IBCSG)U10CA021115 · NCI · UNIVERSITY OF WISCONSIN MADISON · PI COMIS, ROBERT L · 1985 to 2013
$132.6MECOG-ACRIN Biospecimen Bank to Support NCTNU24CA196172 · NCI · ECOG-ACRIN MEDICAL RESEARCH FOUNDATION · PI STANLEY R. HAMILTON, Scott D Jewell · 2015 to 2026
$41.1MECOG Specimen BankingU24CA114737 · NCI · FRONTIER SCI &TECHNOLOGY RSCH FDN, INC · PI COMIS, ROBERT L · 2005 to 2014
$9.3MPROFESSIONAL ONCOLOGY EDUCATION PROGRAMR25CA023944 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI SUZANNE A. GRONEMEYER · 1986 to 2026
$8.3MECOG-ACRIN INTEGRATED LEUKEMIA TRANSLATIONAL RESEARCH CENTERU10CA180827 · NCI · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI LEVINE, ROSS L, MELNICK, ARI M. · 2014 to 2018
$3.0MMOLECULAR SIGNATURES FOR OUTCOME PREDICTION AND THERAPEUTIC TARGETING IN ALLU01CA157937 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI HUNGER, STEPHEN PATRICK, WILLMAN, CHERYL LYNN · 2011 to 2015
$2.9MGENOMIC ANALYSIS OF ADOLESCENT AND YOUNG ADULT ACUTE LYMPHOBLASTIC LEUKEMIARC1CA145707 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI MULLIGHAN, CHARLES G., WILLMAN, CHERYL LYNN · 2009 to 2010
$1.0MCCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001ENCI NIH HHS P30 CA021765NCI NIH HHS R25 CA023944NCI NIH HHS R25 CA23944NCI NIH HHS RC1 CA145707NCI NIH HHS U01 CA157937NCI NIH HHS U10 CA021115NCI NIH HHS U10 CA180820NCI NIH HHS U10 CA180827NCI NIH HHS U10 CA21115NCI NIH HHS U24 CA114737NCI NIH HHS U24-CA114737NCI NIH HHS U24 CA196172
Abstract
Alterations of IKZF1, encoding the lymphoid transcription factor IKAROS, are a hallmark of high-risk acute lymphoblastic leukemia (ALL), however the role of IKZF1 alterations in ALL pathogenesis is poorly understood. Here, we show that in mouse models of BCR-ABL1 leukemia, Ikzf1 and Arf alterations synergistically promote the development of an aggressive lymphoid leukemia. Ikzf1 alterations result in acquisition of stem cell-like features, including self-renewal and increased bone marrow stromal adhesion. Retinoid receptor agonists reversed this phenotype, partly by inducing expression of IKZF1, resulting in abrogation of adhesion and self-renewal, cell cycle arrest, and attenuation of proliferation without direct cytotoxicity. Retinoids potentiated the activity of dasatinib in mouse and human BCR-ABL1 ALL, providing an additional therapeutic option in IKZF1-mutated ALL.
Indexed as
AnimalsCell Cycle CheckpointsFusion Proteins, bcr-ablHumansIkaros Transcription FactorMiceMutationPrecursor Cell Lymphoblastic Leukemia-LymphomaReceptors, Retinoic AcidRetinoidsFusion Proteins, bcr-ablIkaros Transcription FactorReceptors, Retinoic AcidRetinoids
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.