Evidence map›Paper›PMID 26321183›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2015

mRNA: Fulfilling the Promise of Gene Therapy.

Drew Weissman, Katalin Karikó

Abstract readComment
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Art as a multiplier of science communication.Journal of clinical and translational science · 2026
    Article
  7. Messenger RNA vaccines in the prevention of allergic diseases.The World Allergy Organization journal · 2025
    Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Recent progress in mRNA cancer vaccines.Human vaccines & immunotherapeutics · 2024
    Review
  15. Review
  16. Review
  17. mRNA vaccines in disease prevention and treatment.Signal transduction and targeted therapy · 2023
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Drew WeissmanDivision of Infectious Diseases, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Katalin KarikóBioNTech RNA Pharmaceuticals, Mainz, Germany.

Funding

Nucleoside modified mRNA based HIV vaccineR01AI124429 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI WEISSMAN, DREW · 2016 to 2019
$3.4M
NIAID NIH HHS R01 AI124429
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Gene ExpressionGenetic TherapyAnimalsHumansRNA, MessengerRNA, Messenger

Identifiers

PMID26321183
PMCPMC4817894

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.