ArticleDevelopmental cell2015
The Regulatory Landscape of Lineage Differentiation in a Metazoan Embryo.
Article in Developmental cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 68 citations in OpenAlex.
- Computational approaches for multimodal lineage tracing.Nature reviews. Genetics · 2026Review
- Article
- Rapid canalization of chromosome conformation-transcription fingerprints during embryogenesis revealed by fully-automated cell identity decoding with CeSCALE.bioRxiv : the preprint server for biology · 2025Article
- An updated compendium of Caenorhabditis elegans RNA-binding proteins and their regulation.G3 (Bethesda, Md.) · 2025Article
- Low dimensionality of phenotypic space as an emergent property of coordinated teams in biological regulatory networks.iScience · 2025Article
- DeepKymoTracker: A tool for accurate construction of cell lineage trees for highly motile cells.PloS one · 2025Article
- Article
- ARID1A safeguards the canalization of the cell fate decision during osteoclastogenesis.Nature communications · 2024Article
- Article
- A mathematical framework for understanding the spontaneous emergence of complexity applicable to growing multicellular systems.PLoS computational biology · 2024Article
- A lineage-resolved cartography of microRNA promoter activity in C. elegans empowers multidimensional developmental analysis.Nature communications · 2024Article
- A neural network-based model framework for cell-fate decisions and development.Communications biology · 2024Article
- Automated Cell Lineage Reconstruction using Label-Free 4D Microscopy.bioRxiv : the preprint server for biology · 2024Article
- Novel metrics reveal new structure and unappreciated heterogeneity in Caenorhabditis elegans development.PLoS computational biology · 2023Article
- A compound PCP scheme underlies sequential rosettes-based cell intercalation.Development (Cambridge, England) · 2023Article
- Lineage Landscape: a comprehensive database that records lineage commitment across species.Nucleic acids research · 2023Article
- Systematic analysis of cell morphodynamics inFrontiers in bioinformatics · 2023Article
- Delineating the mechanisms and design principles ofComputational and structural biotechnology journal · 2022Review
- Hierarchical deep reinforcement learning reveals novel mechanism of cell movement.Nature machine intelligence · 2022Article
- A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis.Nature methods · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Elucidating the mechanism of cell lineage differentiation is critical for our understanding of development and fate manipulation. Here we combined systematic perturbation and direct lineaging to map the regulatory landscape of lineage differentiation in early C. elegans embryogenesis. High-dimensional phenotypic analysis of 204 essential genes in 1,368 embryos revealed that cell lineage differentiation follows a canalized landscape with barriers shaped by lineage distance and genetic robustness. We assigned function to 201 genes in regulating lineage differentiation, including 175 switches of binary fate choices. We generated a multiscale model that connects gene networks and cells to the experimentally mapped landscape. Simulations showed that the landscape topology determines the propensity of differentiation and regulatory complexity. Furthermore, the model allowed us to identify the chromatin assembly complex CAF-1 as a context-specific repressor of Notch signaling. Our study presents a systematic survey of the regulatory landscape of lineage differentiation of a metazoan embryo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.