Evidence map›Paper›PMID 26321127›Full record

ArticleDevelopmental cell2015

Adaptive Immune Regulation of Mammary Postnatal Organogenesis.

Vicki Plaks, Bijan Boldajipour, Jelena R Linnemann, Nguyen H Nguyen, Kelly Kersten, Yochai Wolf, Amy-Jo Casbon, Niwen Kong, Renske J E van den Bijgaart, Dean Sheppard and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 108 citations in OpenAlex.

  1. Review
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  14. Adult withdrawal of long-term Benzophenone-3 treatment induces regression of mammary ductal branching in a diet-dependent manner.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2025
    Article
  15. Review
  16. Mechanisms of Regulation of Cell Fate in Breast Development and Cancer.Advances in experimental medicine and biology · 2025
    Review
  17. Review
  18. Article
  19. Immune Cell Contribution to Mammary Gland Development.Journal of mammary gland biology and neoplasia · 2024
    Review
  20. Review

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Vicki PlaksDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: vicki.plaks@ucsf.edu.
Bijan BoldajipourDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
Jelena R LinnemannDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
Nguyen H NguyenDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
Kelly KerstenDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
Yochai WolfDepartment of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel.
Amy-Jo CasbonDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
Niwen KongDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
Renske J E van den BijgaartDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
Dean SheppardLung Biology Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Andrew C MeltonLung Biology Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Matthew F KrummelDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
Zena WerbDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: zena.werb@ucsf.edu.
University of California, San Francisco · USWeizmann Institute of Science · IL

Funding

Understanding Asthma EndotypesU19AI077439 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI David J Erle · 2008 to 2026
$41.1M
Tools for Analysis of Airway InflammationP01HL024136 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRUMMEL, MATTHEW F · 1985 to 2014
$23.3M
Sulfs and Injury Repair in Mucosal EpitheliaP01AI053194 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ENGEL, JOANNE N. · 2002 to 2012
$13.4M
Molecular and Cellular Mechanisms in CancerT32CA108462 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GOGA, ANDREI · 2004 to 2024
$10.4M
Role of Metalloproteinases in Mammary Gland RemodelingR01CA057621 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WERB, ZENA · 1993 to 2017
$9.0M
In Vivo Function of Pulmonary IntegrinsR37HL053949 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SHEPPARD, DEAN · 2007 to 2013
$2.7M
Environmental Effect on the Mammary Gland across the LifespanU01ES019458 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WERB, ZENA · 2010 to 2014
$2.5M
IN VIVO FUNCTIONS OF PULMONARY INTEGRINSR01HL053949 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SHEPPARD, DEAN · 1995 to 2006
$2.5M
Collaborative Innate-Adaptive Immune Regulation of Tumor ProgressionU01CA141451 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRUMMEL, MATTHEW F · 2009 to 2013
$2.2M
NCI NIH HHS CA057621NCI NIH HHS CA141451NCI NIH HHS R01 CA057621NCI NIH HHS T32 CA108462NCI NIH HHS U01 CA141451NHLBI NIH HHS HL024136NHLBI NIH HHS HL53949NHLBI NIH HHS P01 HL024136NHLBI NIH HHS R01 HL053949NHLBI NIH HHS R37 HL053949NIAID NIH HHS AI053194NIAID NIH HHS AI077439NIAID NIH HHS P01 AI053194NIAID NIH HHS U19 AI077439NIEHS NIH HHS ES019458NIEHS NIH HHS U01 ES019458
6 · The paper itself

Abstract

Postnatal organogenesis occurs in an immune competent environment and is tightly controlled by interplay between positive and negative regulators. Innate immune cells have beneficial roles in postnatal tissue remodeling, but roles for the adaptive immune system are currently unexplored. Here we show that adaptive immune responses participate in the normal postnatal development of a non-lymphoid epithelial tissue. Since the mammary gland (MG) is the only organ developing predominantly after birth, we utilized it as a powerful system to study adaptive immune regulation of organogenesis. We found that antigen-mediated interactions between mammary antigen-presenting cells and interferon-γ (IFNγ)-producing CD4+ T helper 1 cells participate in MG postnatal organogenesis as negative regulators, locally orchestrating epithelial rearrangement. IFNγ then affects luminal lineage differentiation. This function of adaptive immune responses, regulating normal development, changes the paradigm for studying players of postnatal organogenesis and provides insights into immune surveillance and cancer transformation.

Indexed as

Adaptive ImmunityAnimalsAntigen-Presenting CellsBreastEpithelial CellsEpitheliumFemaleHumansImmunity, InnateInterferon-gammaMiceOrganogenesisInterferon-gamma

Identifiers

PMID26321127
PMCPMC4573906
OpenAlexW2139983295

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.