ArticleCell host & microbe2015
Staphylococcus aureus Targets the Duffy Antigen Receptor for Chemokines (DARC) to Lyse Erythrocytes.
Article in Cell host & microbe, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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72 citing papers in PubMed, 111 citations in OpenAlex.
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- Virulence Phenotypes Differentiate Persistent vs. Resolving Isolates of HumanAntibiotics (Basel, Switzerland) · 2026Article
- The Pathogenicity Mechanisms ofInternational journal of molecular sciences · 2025Review
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- Cell targeting by the bicomponent leukocidin subunit HlgB drives Staphylococcus aureus pathophysiology.The Journal of biological chemistry · 2025Article
- The Susceptibility Profiles of Human Peripheral Blood Cells toMicroorganisms · 2025Review
- Pore Formation by Pore Forming Proteins in Lipid Membranes: Structural Insights Through Cryo-EM.The Journal of membrane biology · 2025Review
- Linking Virulence and Iron Limitation Response inJournal of proteome research · 2025Article
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- Microbial adaptive pathogenicity strategies to the host inflammatory environment.FEMS microbiology reviews · 2025Review
- Evolution of strain diversity and virulence factor repertoire in pediatric Staphylococcus aureus isolates.PloS one · 2025Article
- Environmental alkalization suppresses deployment of virulence strategies inJournal of bacteriology · 2024Article
- Atypical chemokine receptors in the immune system.Nature reviews. Immunology · 2024Review
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- Mechanisms of host adaptation by bacterial pathogens.FEMS microbiology reviews · 2024Review
- Determinants of bacterial survival and proliferation in blood.FEMS microbiology reviews · 2024Review
- Collaborative Cross mice have diverse phenotypic responses to infection with Methicillin-resistant Staphylococcus aureus USA300.PLoS genetics · 2024Article
12 more citing papers are in PubMed but not listed here.
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16 authors at 5 institutions in 4 countries.
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Abstract
In order for Staphylococcus aureus to thrive inside the mammalian host, the bacterium has to overcome iron scarcity. S. aureus is thought to produce toxins that lyse erythrocytes, releasing hemoglobin, the most abundant iron source in mammals. Here we identify the Duffy antigen receptor for chemokines (DARC) as the receptor for the S. aureus hemolytic leukocidins LukED and HlgAB. By assessing human erythrocytes with DARC polymorphisms, we determined that HlgAB- and LukED-mediated lysis directly relates to DARC expression. DARC is required for S. aureus-mediated lysis of human erythrocytes, and DARC overexpression is sufficient to render cells susceptible to toxin-mediated lysis. HlgA and LukE bind directly to DARC through different regions, and by targeting DARC, HlgAB and LukED support S. aureus growth in a hemoglobin-acquisition-dependent manner. These findings elucidate how S. aureus targets and lyses erythrocytes to release one of the scarcest nutrients within the mammalian host.
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