ArticleJournal of extracellular vesicles2015
Extracellular RNAs: development as biomarkers of human disease.
Abstract read
In one paragraph
Article in Journal of extracellular vesicles, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed.
- The RNA structural code: orchestrating gene expression and enabling precision therapies.Acta pharmacologica Sinica · 2026Review
- RNY1 Is Heterogeneously Partitioned in Inflamed Airway Fluid and Modulates Pro-Inflammatory Macrophage Transcriptional Programming.Journal of extracellular biology · 2026Article
- Extracellular RNAs as Messengers and Early Biomarkers in Neurodegeneration.International journal of molecular sciences · 2025Review
- RNY1 partitions into extracellular vesicles and ribonucleoprotein particles during airway inflammation to regulate macrophage programming.bioRxiv : the preprint server for biology · 2025Article
- Stability of microRNAs in serum and plasma reveal promise as a circulating biomarker.Non-coding RNA research · 2025Article
- Cardiometabolic Therapies Shape Non-Coding RNA Landscapes in Cardiovascular Fibrosis.Metabolites · 2025Review
- PIWIL genes in hepatocellular carcinoma: a multi-omics approach uncovering dysregulated expression and ceRNA networks in mice.BMC genomic data · 2024Article
- Choice of blood collection methods influences extracellular vesicles counts and miRNA profiling.Journal of extracellular biology · 2024Article
- Immunoactive signatures of circulating tRNA- and rRNA-derived RNAs in chronic obstructive pulmonary disease.Molecular therapy. Nucleic acids · 2024Article
- Plasma Extracellular MicroRNAs Associated With Cardiovascular Disease Risk Factors in Middle-Aged and Older Adults.Journal of the American Heart Association · 2024Article
- Immunostimulatory short non-coding RNAs in the circulation of patients with tuberculosis infection.Molecular therapy. Nucleic acids · 2024Article
- Analysis of the longitudinal stability of human plasma miRNAs and implications for disease biomarkers.Scientific reports · 2024Article
- Elevated expression patterns of P-element Induced Wimpy Testis (PIWI) transcripts are potential candidate markers for Hepatocellular Carcinoma.Cancer biomarkers : section A of Disease markers · 2024Article
- Morphometric and Nanomechanical Screening of Peripheral Blood Cells with Atomic Force Microscopy for Label-Free Assessment of Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis.International journal of molecular sciences · 2023Review
- Phospho-RNA-Seq Highlights Specific Small RNA Profiles in Plasma Extracellular Vesicles.International journal of molecular sciences · 2023Article
- Article
- Thermodynamic Signatures of Blood Plasma Proteome in Neurodegenerative Pathologies.International journal of molecular sciences · 2023Article
- Article
- Distinct Stress-Dependent Signatures of Cellular and Extracellular tRNA-Derived Small RNAs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- A cerebrospinal fluid microRNA analysis: Progressive supranuclear palsy.Molecular medicine reports · 2022Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Joseph F QuinnDepartment of Neurology, Oregon Health & Science University, Portland, OR, USA; quinnj@ohsu.edu.
Tushar PatelDepartments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.
David WongSchool of Dentistry, Department of Head and Neck Surgery, University of California at Los Angeles, Los Angeles, CA, USA.
Saumya DasDivision of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Jane E FreedmanDepartment of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Louise C LaurentDepartment of Reproductive Medicine, University of California at San Diego, San Diego, CA, USA.
Bob S CarterDepartment of Neurosurgery, University of California at San Diego, San Diego, CA, USA.
Fred HochbergDepartment of Neurosurgery, University of California at San Diego, San Diego, CA, USA.
Kendall Van Keuren-JensenTranslational Genomics Research Institute, Phoenix, AZ, USA.
Matt HuentelmanTranslational Genomics Research Institute, Phoenix, AZ, USA.
Robert SpetzlerBarrow Neurological Institute, Department of Neurological Surgery, St. Joseph's Hospital & Medical Center, Phoenix, AZ, USA.
M Yashar S KalaniBarrow Neurological Institute, Department of Neurological Surgery, St. Joseph's Hospital & Medical Center, Phoenix, AZ, USA.
Jorge ArangoBarrow Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ, USA.
P David AdelsonBarrow Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ, USA.
Howard L WeinerAnn Romney Center for Neurologic Disease, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Roopali GandhiAnn Romney Center for Neurologic Disease, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Beatrice GoilavDivision of Pediatric Nephrology, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA.
Chaim PuttermanDivision of Rheumatology and Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Julie A SaugstadDepartment of Anesthesiology & Perioperative Medicine, Oregon Health & Science University, Portland, OR, USA; saugstad@ohsu.edu.
Funding
Outreach, Recruitment and Education CoreP30AG008017 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI DODGE, HIROKO HAYAMA · 1990 to 2019
$27.7MTranslational Research Skills Development CoreU54HL112311 · NHLBI · UNIVERSITY OF UTAH · PI WEYRICH, ANDREW S, ZIMMERMAN, GUY A. · 2012 to 2016
$12.9MPlasma miRNA predictors of adverse mechanical and electrical remodeling after MIUH3TR000901 · NCATS · MASSACHUSETTS GENERAL HOSPITAL · PI DAS, SAUMYA, KWONG, RAYMOND Y · 2015 to 2017
$3.2MExtracellular RNAs: Biomarkers for Cardiovascular Risk and DiseaseUH3TR000921 · NCATS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FREEDMAN, JANE E · 2015 to 2017
$3.1MexRNA signatures Predict Outcomes after brain injuryUH3TR000891 · NCATS · TRANSLATIONAL GENOMICS RESEARCH INST · PI ADELSON, P. DAVID, HUENTELMAN, MATT · 2015 to 2017
$3.0MexRNA Biomarkers for Human GliomaUH3TR000931 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CARTER, BOB S, HOCHBERG, FRED H · 2015 to 2017
$3.0MExtracellular non-coding RNA biomarkers of hepatocellular cancerUH3TR000884 · NCATS · MAYO CLINIC JACKSONVILLE · PI PATEL, TUSHAR · 2015 to 2017
$3.0MClinical Utility of Salivary ExRNA Biomarkers for Gastric Cancer DetectionUH3TR000923 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WONG, DAVID T · 2015 to 2017
$2.7MClinical utility of extracellular RNA as marker of kidney disease progressionUH3TR000933 · NCATS · ROCKEFELLER UNIVERSITY · PI SUTHANTHIRAN, MANIKKAM, TUSCHL, THOMAS · 2015 to 2017
$2.5MNovel Role for Circulating extracellular RNAs in Human Heart FailureR01HL122547 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI DAS, SAUMYA · 2015 to 2019
$2.1MOptimization and Normalization Studies for Individual CSF SamplesUH3TR000903 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI QUINN, JOSEPH F, SAUGSTAD, JULIE ANNE · 2015 to 2016
$1.2MOptimization and Normalization Studies for CSF as a BiomarkerUH2TR000891 · NCATS · TRANSLATIONAL GENOMICS RESEARCH INST · PI ADELSON, P. DAVID, HUENTELMAN, MATT · 2013 to 2014
$1.1MNCATS NIH HHS UH2 TR000884NCATS NIH HHS UH2 TR000890NCATS NIH HHS UH2 TR000891NCATS NIH HHS UH2 TR000901NCATS NIH HHS UH2 TR000903NCATS NIH HHS UH2 TR000906NCATS NIH HHS UH2 TR000921NCATS NIH HHS UH2 TR000923NCATS NIH HHS UH2 TR000931NCATS NIH HHS UH2 TR000933NCATS NIH HHS UH3 TR000884NCATS NIH HHS UH3 TR000890NCATS NIH HHS UH3 TR000891NCATS NIH HHS UH3 TR000901NCATS NIH HHS UH3 TR000903NCATS NIH HHS UH3 TR000906NCATS NIH HHS UH3 TR000921NCATS NIH HHS UH3 TR000923NCATS NIH HHS UH3 TR000931NCATS NIH HHS UH3 TR000933NHLBI NIH HHS R01 HL122547NHLBI NIH HHS U54 HL112311NIA NIH HHS P30 AG008017
Abstract
Ten ongoing studies designed to test the possibility that extracellular RNAs may serve as biomarkers in human disease are described. These studies, funded by the NIH Common Fund Extracellular RNA Communication Program, examine diverse extracellular body fluids, including plasma, serum, urine and cerebrospinal fluid. The disorders studied include hepatic and gastric cancer, cardiovascular disease, chronic kidney disease, neurodegenerative disease, brain tumours, intracranial haemorrhage, multiple sclerosis and placental disorders. Progress to date and the plans for future studies are outlined.
Indexed as
biomarkersERCCexRNAextracellular RNA
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.