New class of 8-aryl-7-deazaguanine cell permeable fluorescent probes.

Ilirian Dhimitruka, Timothy D Eubank, Amy C Gross, Valery V Khramtsov

Abstract read

In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ilirian DhimitrukaDorothy M. Davis Heart & Lung Research Institute, and Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, United States.

Timothy D EubankDepartment of Microbiology, Immunology, and Cell Biology, West Virginia University Health Sciences, Morgantown, VW 26506, United States.

Amy C GrossDorothy M. Davis Heart & Lung Research Institute, and Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, United States.

Valery V KhramtsovDorothy M. Davis Heart & Lung Research Institute, and Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, United States.

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Anne Courtney DeVries · 2012 to 2026

$81.0M

Synthesis of a dual pH-pO2 hydromethyl trityl probe for EPR imaging in vivoR03EB016859 · NIBIB · OHIO STATE UNIVERSITY · PI DHIMITRUKA, ILIRIAN · 2013 to 2014

$151k

NIBIB NIH HHS R03 EB016859NIGMS NIH HHS U54 GM104942

6 · The paper itself

Abstract

A one step synthesis of fluorescent 8-aryl-(7-deazaguanines) has been accomplished. Probes exhibit blue to green high quantum yield fluorescence in a variety of organic and aqueous solutions, high extinction coefficients, and large Stokes shifts often above 100 nm. The probes are highly cell permeable, and exhibit stable bright fluorescence once intracellular; therefore are suited to the design of biosensors.

Indexed as

Cell Membrane PermeabilityAzaguanineCell Line, TumorFluorescenceFluorescent DyesHumansKB CellsMicroscopy, ConfocalMolecular StructureAzaguanineFluorescent Dyes2,4-Diamino-6-hydroxypyrimidine8-Aryl-7-deazaguanineCellular permeabilityFluorescent probesPhenacyl bromides

Identifiers

PMID26320620

DOI10.1016/j.bmcl.2015.08.054

PMCPMC4592842

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.