ArticleThe Plant cell2015
A System for Dosage-Based Functional Genomics in Poplar.
Article in The Plant cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- A simple method to efficiently generate structural variation in plants.PLoS genetics · 2025Article
- Sterility and structural variation in an arabidopsis pedigree carrying a ring minichromosome.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2025Article
- Evolution and functioning of an X-A balance sex-determining system in hops.Nature plants · 2025Article
- TPS5 and TOR signaling components are determinants ofFrontiers in plant science · 2025Article
- Induced and natural variation affect traits independently in hybrid Populus.G3 (Bethesda, Md.) · 2024Article
- Plant Functional Genomics Based on High-Throughput CRISPR Library Knockout Screening: A Perspective.Advanced genetics (Hoboken, N.J.) · 2024Article
- Identification of Induced Copy Number Variation from Low Coverage Sequence Data.Methods in molecular biology (Clifton, N.J.) · 2024Article
- A systems genetic analysis identifies putative mechanisms and candidate genes regulating vessel traits in poplar wood.Frontiers in plant science · 2024Article
- Genome sequence analysis provides insights into the mode of 2n egg formation in Solanum malmeanum.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Establishment and inheritance of minichromosomes from Arabidopsis haploid induction.Chromosoma · 2023Article
- Genome-scale targeted mutagenesis inGenome research · 2023Article
- ThePNAS nexus · 2023Article
- Chromoanagenesis in the asy1 meiotic mutant of Arabidopsis.G3 (Bethesda, Md.) · 2023Article
- Identification and Functional Prediction of CircRNAs in Leaves of F1 Hybrid Poplars with Different Growth Potential and Their Parents.International journal of molecular sciences · 2023Article
- Development of a simple multiple mutation detection system using seed-coat flavonoid pigments in irradiated Arabidopsis MScientific reports · 2022Article
- Spectrum and Density of Gamma and X-ray Induced Mutations in a Non-Model Rice Cultivar.Plants (Basel, Switzerland) · 2022Article
- Article
- Frequency and Spectrum of Mutations Induced by Gamma Rays Revealed by Phenotype Screening and Whole-Genome Re-Sequencing inInternational journal of molecular sciences · 2022Article
- Detection and characterization of genome-wide mutations in M1 vegetative cells of gamma-irradiated Arabidopsis.PLoS genetics · 2022Article
- Diploid mint (M. longifolia) can produce spearmint type oil with a high yield potential.Scientific reports · 2021Article
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4 authors.
Funding
Abstract
Altering gene dosage through variation in gene copy number is a powerful approach to addressing questions regarding gene regulation, quantitative trait loci, and heterosis, but one that is not easily applied to sexually transmitted species. Elite poplar (Populus spp) varieties are created through interspecific hybridization, followed by clonal propagation. Altered gene dosage relationships are believed to contribute to hybrid performance. Clonal propagation allows for replication and maintenance of meiotically unstable ploidy or structural variants and provides an alternative approach to investigating gene dosage effects not possible in sexually propagated species. Here, we built a genome-wide structural variation system for dosage-based functional genomics and breeding of poplar. We pollinated Populus deltoides with gamma-irradiated Populus nigra pollen to produce >500 F1 seedlings containing dosage lesions in the form of deletions and insertions of chromosomal segments (indel mutations). Using high-precision dosage analysis, we detected indel mutations in ∼55% of the progeny. These indels varied in length, position, and number per individual, cumulatively tiling >99% of the genome, with an average of 10 indels per gene. Combined with future phenotype and transcriptome data, this population will provide an excellent resource for creating and characterizing dosage-based variation in poplar, including the contribution of dosage to quantitative traits and heterosis.
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