ArticlePhysiological reports2015
Rapid onset vasodilation with single muscle contractions in the leg: influence of age.
Article in Physiological reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Dietary nitrate does not acutely enhance skeletal muscle blood flow and vasodilation in the lower limbs of older adults during single-limb exercise.European journal of applied physiology · 2020Trial
- Acute circulatory and femoral hemodynamic responses induced by standing core exercise at different rotational cadence: a crossover study.BMC sports science, medicine & rehabilitation · 2022Article
- Impact of Interrepetition Rest on Muscle Blood Flow and Exercise Tolerance during Resistance Exercise.Medicina (Kaunas, Lithuania) · 2022Article
- Sex-related differences in rapid-onset vasodilation: impact of aging.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Exercising for Insulin Sensitivity - Is There a Mechanistic Relationship With Quantitative Changes in Skeletal Muscle Mass?Frontiers in physiology · 2021Review
- Assessment of resistance vessel function in human skeletal muscle: guidelines for experimental design, Doppler ultrasound, and pharmacology.American journal of physiology. Heart and circulatory physiology · 2020Review
- Aerobic Exercise Improves Microvascular Function in Older Adults.Medicine and science in sports and exercise · 2019Article
- Habitual exercise training in older adults offsets the age-related prolongation in leg vasodilator kinetics during single-limb lower body exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- CORP: Ultrasound assessment of vascular function with the passive leg movement technique.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Review
- Age Reduces Microvascular Function in the Leg Independent of Physical Activity.Medicine and science in sports and exercise · 2017Article
- Sympathetic nervous system activation reduces contraction-induced rapid vasodilation in the leg of humans independent of age.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Chronic endurance exercise training offsets the age-related attenuation in contraction-induced rapid vasodilation.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- A 'passive' movement into the future of assessing endothelial dysfunction?The Journal of physiology · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The influence of aging on contraction-induced rapid vasodilation has been well characterized in the forearm. We sought to examine the impact of aging on contraction-induced rapid vasodilation in the leg following single muscle contractions and determine whether potential age-related impairments were similar between limbs (leg vs. arm). Fourteen young (23 ± 1 years) and 16 older (66 ± 1 years) adults performed single leg knee extensions at 20%, 40%, and 60% of work rate maximum. Femoral artery diameter and blood velocity were measured using Doppler ultrasound. Limb vascular conductance (VC) was calculated using blood flow (mL·min(-1)) and mean arterial pressure (mmHg). Peak and total vasodilator responses in the leg (change [Δ] in VC from baseline) were blunted in older adults by 44-50% across exercise intensities (P < 0.05 for all). When normalized for muscle mass, age-related differences were still evident (P < 0.05). Comparing the rapid vasodilator responses between the arm and the leg of the same individuals at similar relative intensities (20% and 40%) reveals that aging influences peak and total vasodilation equally between the limbs (no significant age × limb interaction at either intensity, P = 0.28-0.80). Our data demonstrate that (1) older adults exhibit an attenuated rapid hyperemic and vasodilator response in the leg; and (2) the age-related reductions in rapid vasodilation are similar between the arm and the leg. The mechanisms contributing to the age-related differences in contraction-induced rapid vasodilation are perhaps similar to those seen with the forearm model, but have not been confirmed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.