Evidence map›Paper›PMID 26320033›Full record

ArticleInternational journal of epidemiology2016

Alcohol consumption and breast cancer risk by estrogen receptor status: in a pooled analysis of 20 studies.

Seungyoun Jung, Molin Wang, Kristin Anderson, Laura Baglietto, Leif Bergkvist, Leslie Bernstein, Piet A van den Brandt, Louise Brinton, Julie E Buring, A Heather Eliassen and 31 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 8 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 8 syntheses or guidelines pooled it, 168 citations in OpenAlex.

  1. Pooled it
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  12. Epidemiology, early detection, and management of breast cancer in China: A comprehensive review.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2025
    Article
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  20. Breast cancer: pathogenesis and treatments.Signal transduction and targeted therapy · 2025
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23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors at 20 institutions in 9 countries.

Seungyoun JungDepartment of Nutrition, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA, sjung@epi.umaryland.edu.
Molin WangDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA, Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Kristin AndersonDivision of Epidemiology and Community Health, School of Public Health, and Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Laura BagliettoCancer Epidemiology Centre, Cancer Council Victoria, Carlton, VIC, Australia, Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, VIC, Australia.
Leif BergkvistDepartment of Surgery and Centre for Clinical Research, Central Hospital, Västerås, Sweden.
Leslie BernsteinDivision of Cancer Etiology, Department of Population Science, Beckman Research Institute and City of Hope National Medical Center, Duarte, CA, USA.
Piet A van den BrandtDepartment of Epidemiology, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.
Louise BrintonDivision of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, Bethesda, MD, USA.
Julie E BuringDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA, Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
A Heather EliassenDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA, Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Roni FalkDivision of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, Bethesda, MD, USA.
Susan M GapsturEpidemiology Research Program, American Cancer Society, Atlanta, GA, USA.
Graham G GilesCancer Epidemiology Centre, Cancer Council Victoria, Carlton, VIC, Australia, Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, VIC, Australia.
Gary GoodmanDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Judith Hoffman-BoltonDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Pamela L Horn-RossCancer Prevention Institute of California, Fremont, CA, USA.
Manami InoueEpidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan, AXA Department of Health and Human Security, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Laurence N KolonelEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.
Vittorio KroghEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Marie LofDepartment of Clinical and Experimental Medicine, University of Linköping, Linköping, Sweden.
Paige MaasDivision of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, Bethesda, MD, USA.
Anthony B MillerDalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Marian L NeuhouserDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Yikyung ParkDivision of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St Louis, St Louis, MO, USA.
Kim RobienDepartment of Epidemiology and Biostatistics, Milken Institute School of Public Health, George Washington University, Washington, DC, USA.
Thomas E RohanDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Stephanie ScarmoDivision of Epidemiology, Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA.
Leo J SchoutenDepartment of Epidemiology, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.
Sabina SieriEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Victoria L StevensEpidemiology Research Program, American Cancer Society, Atlanta, GA, USA.
Schoichiro TsuganeEpidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan.
Kala VisvanathanDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Lynne R WilkensEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.
Alicja WolkDivision of Nutritional Epidemiology, National Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
Elisabete WeiderpassDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden, Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway, Department of Research, Cancer Registry of Norway, Oslo, Norway and Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland.
Walter C WillettDepartment of Nutrition, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA, Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Anne Zeleniuch-JacquotteDivision of Epidemiology, Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA.
Shumin M ZhangDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Xuehong ZhangChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Regina G ZieglerDivision of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, Bethesda, MD, USA.
Stephanie A Smith-WarnerDepartment of Nutrition, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Harvard University · USDivision of Cancer Epidemiology and GeneticsAmerican Cancer Society · USBrigham and Women's Hospital · USCancer Council Victoria · AUFondazione IRCCS Istituto Nazionale dei Tumori · ITFred Hutch Cancer Center · USJohns Hopkins University · USMaastricht University · NLNew York University · USAlbert Einstein College of Medicine · USCancer Center of Hawaii · USCancer Prevention Institute of California · USCity Of Hope National Medical Center · USKarolinska Institutet · SELinköping University · SEMilken Institute · USNational Cancer Institute · USThe University of Tokyo · JPUiT The Arctic University of Norway · NO

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Thomas James Lynch · 1985 to 2026
$296.4M
University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Xin Chen · 1996 to 2026
$56.2M
Understanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4M
THE CAROTENE AND RETINOL EFFICACY TRIAL (CARET)U01CA063673 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GOODMAN, GARY E · 1994 to 2006
$13.0M
The Women's Health Study: Infrastructure Support for Continued Cohort Follow-upUM1CA182913 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 2014 to 2018
$4.0M
The NYU Women's Health StudyUM1CA182934 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ZELENIUCH-JAQUOTTE, ANNE · 2015 to 2019
$3.7M
INFRASRUCTURE SUPPORT AND DATA ENHANCEMENTS FOR THE CARET BIOREPOSITORYUM1CA167462 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GOODMAN, GARY E · 2013 to 2017
$2.8M
NCI NIH HHS P30 CA015704NCI NIH HHS P30 CA071789NCI NIH HHS U01 CA063673NCI NIH HHS U01 CA164973NCI NIH HHS UM1 CA167462NCI NIH HHS UM1 CA182913NCI NIH HHS UM1 CA182934
6 · The paper itself

Abstract

backgroundBreast cancer aetiology may differ by estrogen receptor (ER) status. Associations of alcohol and folate intakes with risk of breast cancer defined by ER status were examined in pooled analyses of the primary data from 20 cohorts.

methodsDuring a maximum of 6-18 years of follow-up of 1 089 273 women, 21 624 ER+ and 5113 ER- breast cancers were identified. Study-specific multivariable relative risks (RRs) were calculated using Cox proportional hazards regression models and then combined using a random-effects model.

resultsAlcohol consumption was positively associated with risk of ER+ and ER- breast cancer. The pooled multivariable RRs (95% confidence intervals) comparing ≥ 30 g/d with 0 g/day of alcohol consumption were 1.35 (1.23-1.48) for ER+ and 1.28 (1.10-1.49) for ER- breast cancer (Ptrend ≤ 0.001; Pcommon-effects by ER status: 0.57). Associations were similar for alcohol intake from beer, wine and liquor. The associations with alcohol intake did not vary significantly by total (from foods and supplements) folate intake (Pinteraction ≥ 0.26). Dietary (from foods only) and total folate intakes were not associated with risk of overall, ER+ and ER- breast cancer; pooled multivariable RRs ranged from 0.98 to 1.02 comparing extreme quintiles. Following-up US studies through only the period before mandatory folic acid fortification did not change the results. The alcohol and folate associations did not vary by tumour subtypes defined by progesterone receptor status.

conclusionsAlcohol consumption was positively associated with risk of both ER+ and ER- breast cancer, even among women with high folate intake. Folate intake was not associated with breast cancer risk.

Indexed as

AdultAgedAged, 80 and overAlcohol DrinkingBreast NeoplasmsDietary SupplementsEthanolFemaleFolic AcidHumansMiddle AgedMultivariate AnalysisProportional Hazards ModelsProspective StudiesReceptors, EstrogenRisk FactorsEthanolFolic AcidReceptors, EstrogenAlcoholbreast cancercohort studyepidemiologyestrogen receptorfolatepooled analysesprogesterone receptor

Identifiers

PMID26320033
PMCPMC5005939
OpenAlexW1894675522

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.