Evidence map›Paper›PMID 26319974›Full record

ArticleThe Journal of surgical research2016

Fluid administration and morbidity in transhiatal esophagectomy.

Oliver S Eng, Renee L Arlow, Dirk Moore, Chunxia Chen, John E Langenfeld, David A August, Darren R Carpizo

Abstract readEvaluation Study
In one paragraph

Article in The Journal of surgical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Observational
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Oliver S EngDepartment of Surgery, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, 08903.
Renee L ArlowDepartment of Surgery, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, 08903.
Dirk MooreDepartment of Biostatistics, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, 08903; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, 08903.
Chunxia ChenDepartment of Biostatistics, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, 08903; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, 08903.
John E LangenfeldDepartment of Surgery, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, 08903; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, 08903.
David A AugustDepartment of Surgery, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, 08903; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, 08903.
Darren R CarpizoDepartment of Surgery, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, 08903; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, 08903. Electronic address: carpizdr@cinj.rutgers.edu.

Funding

Exploration of a Mutant p53 Reactivating CompoundK08CA172676 · NCI · RBHS -CANCER INSTITUTE OF NEW JERSEY · PI CARPIZO, DARREN RICHARD · 2013 to 2017
$745k
NCI NIH HHS K08 CA172676
6 · The paper itself

Abstract

backgroundEsophagectomy is associated with significant morbidity. Optimizing perioperative fluid administration is one potential strategy to mitigate morbidity. We sought to investigate the relationship of intraoperative fluid (IOF) administration to outcomes in patients undergoing transhiatal esophagectomy with particular attention to malnourished patients, who may be more susceptible to the effects of fluid overload. MATERIAL AND

methodsPatients who underwent transhiatal esophagectomy from 2000-2013 were identified from a retrospective database. IOF rates (mL/kg/hr) were determined and their relationship to outcomes compared. To examine the impact of malnutrition, we stratified patients based on median preoperative serum albumin and compared outcomes. RESULTS AND DISCUSSION: 211 patients comprised the cohort. 74% of patients underwent esophagectomy for esophageal adenocarcinoma. Linear regression analyses were performed comparing independent perioperative variables to four outcomes variables: length of stay, complications per patient, major complications, and Clavien-Dindo classification. IOF rate was significantly associated with three of four outcomes on univariate analysis. Significantly more patients with a preoperative albumin level ≤3.7 g/dL who received more than the median IOF rate experienced more severe complications.

conclusionsIncreased intraoperative fluid administration is associated with perioperative morbidity in patients undergoing transhiatal esophagectomy. Patients with lower preoperative albumin levels may be particularly sensitive to the effects of volume overload.

Indexed as

EsophagectomyAdenocarcinomaAdultAgedAged, 80 and overEsophageal NeoplasmsFemaleFluid TherapyHumansLength of StayLinear ModelsMaleMalnutritionMiddle AgedPerioperative CarePostoperative ComplicationsFluidsMorbidityTranshiatal esophagectomy

Identifiers

PMID26319974
PMCPMC4914131

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.